MAP3K14: Regulation of Cell Signaling Pathways (G9020)

Target Name: MAP3K14

NCBI ID: G9020

MAP3K14

MAP3K14: Regulation of Cell Signaling Pathways

MAP3K14, also known as Mitogen-activated protein kinase kinase 14, is a protein that plays a crucial role in cell signaling pathways. It is a member of the MAPK/ERK signaling pathway, which regulates various cellular processes including cell growth, differentiation, and respond to stimuli.

MAP3K14 is a 21-kDa protein that is expressed in various tissues, including brain, heart, and muscle. It is highly phosphorylated, which means that it has several active sites that can be targeted by small molecules.

One of the unique features of MAP3K14 is its role in cell signaling. It is involved in the regulation of several cellular processes, including cell growth, differentiation, and response to stimuli. It plays a key role in the development and maintenance of neural stem cells , which are essential for the development and repair of brain tissue.

MAP3K14 is also involved in the regulation of cell adhesion. It is a critical regulator of tight junctions, which are responsible for maintaining the integrity of the blood-brain barrier. It helps to maintain the barrier, which is essential for the exchange of nutrients, oxygen, and other substances between the brain and the surrounding environment.

MAP3K14 is also involved in the regulation of cell migration. It plays a key role in the regulation of the migration of neurons, which are essential for the development and function of the nervous system. It helps to ensure that neurons move in a specific direction, which is critical for the formation of neural circuits.

MAP3K14 is also involved in the regulation of cell survival. It plays a key role in the regulation of cell apoptosis, which is the process by which cells die when they are no longer needed. It helps to ensure that cells are able to detect when they are no longer useful, and it allows cells to undergo apoptosis in a controlled manner.

MAP3K14 is also involved in the regulation of inflammation. It plays a key role in the regulation of inflammatory responses, which are essential for the immune system to protect the body against infection. It helps to ensure that inflammation is regulated, which is critical for maintaining the health of the body.

MAP3K14 is also involved in the regulation of the blood-brain barrier. It is a critical regulator of the blood-brain barrier, which is responsible for maintaining the integrity of the barrier and ensuring that substances are able to exchange between the brain and the surrounding environment. It plays a key role in the development and maintenance of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

MAP3K14 is also involved in the regulation of the Hedgehog signaling pathway. It plays a key role in the regulation of the Hedgehog signaling pathway, which is a critical regulator of cell proliferation and survival. It helps to ensure that cells are able to detect when they are in a state of stress, and it allows cells to respond appropriately.

MAP3K14 is also involved in the regulation of cell signaling pathways. It is a critical regulator of several cellular signaling pathways, including the PI3K/AKT signaling pathway, the NF-kappa-B signaling pathway, and the TGF-β signaling pathway. It plays a key role in the regulation of cellular processes, including cell growth, differentiation, and response to stimuli.

MAP3K14 is also involved in the regulation of protein synthesis. It plays a key role in the regulation of protein synthesis, which is the process by which cells produce proteins. It helps to ensure that cells have access to the necessary tools for protein synthesis, including mTOR, which is a critical regulator of protein synthesis.

In conclusion, MAP3K14 is a protein that plays a critical role in several cellular processes, including cell signaling pathways, cell adhesion,

Protein Name: Mitogen-activated Protein Kinase Kinase Kinase 14

Functions: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner

The "MAP3K14 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MAP3K14 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets