MAP3K4: Key Player in MAPK/ERK Signaling (G4216)

Target Name: MAP3K4

NCBI ID: G4216

MAP3K4

MAP3K4: Key Player in MAPK/ERK Signaling

MAP3K4, also known as MEKK4, is a protein that is expressed in various tissues and cell types throughout the body. It is a member of the MAPK/ERK signaling pathway, which is a well-established signaling pathway that plays a crucial role in the regulation of cellular processes such as cell growth, differentiation, and survival. The MAPK/ERK signaling pathway is also known as the MAPK pathway, and it is a highly conserved signaling pathway that is involved in the regulation of many cellular processes that are important for the proper functioning of cells.

MAP3K4 is a 21-kDa protein that is composed of 115 amino acid residues. It is expressed in a variety of tissues, including skeletal muscles, heart, brain, and various cell types. It is also highly expressed in the liver, and it has been shown to be involved in the regulation of cellular processes such as cell growth, differentiation, and apoptosis.

One of the key functions of MAP3K4 is its role in the regulation of cell signaling. It is a part of the MAPK/ERK signaling pathway, and it is involved in the regulation of various cellular processes that are dependent on the MAPK/ERK signaling pathway. This includes the regulation of cell growth, differentiation, and survival. MAP3K4 has been shown to play a crucial role in the regulation of cell proliferation, and it is thought to be involved in the regulation of cell cycle progression.

In addition to its role in cell signaling, MAP3K4 is also involved in the regulation of cellular processes related to inflammation and stress. It has been shown to be involved in the regulation of various cellular processes that are related to inflammation, including the regulation of pain perception and the regulation of the immune response. It is also involved in the regulation of stress responses, including the regulation of stress-induced cellular changes.

MAP3K4 has also been shown to play a role in the regulation of cellular processes related to metabolism and energy homeostasis. It is involved in the regulation of various cellular processes that are related to metabolism and energy homeostasis, including the regulation of cellular energy metabolism and the regulation of the citric acid cycle.

In conclusion, MAP3K4 is a protein that is involved in a variety of cellular processes throughout the body. It is a key player in the MAPK/ERK signaling pathway and is thought to play a crucial role in the regulation of cell signaling, cell growth, differentiation, and apoptosis. It is also involved in the regulation of cellular processes related to inflammation and stress, as well as cellular processes related to metabolism and energy homeostasis. As a result, MAP3K4 is a potential drug target and may be useful in the development of new treatments for a variety of diseases.

Protein Name: Mitogen-activated Protein Kinase Kinase Kinase 4

Functions: Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6

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•   general information;
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•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
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