Trav9-1: A Protein Involved in T Cell Recognition and Communication

Target Name: TRAV9-1

NCBI ID: G28678

TRAV9-1

Other Name(s): T cell receptor alpha variable 9-1 | TCRAV9S1 | TRAV91

Trav9-1: A Protein Involved in T Cell Recognition and Communication

Trav9-1 (T cell receptor alpha variable 9-1) is a protein that is expressed in T cells, a type of white blood cell that plays a crucial role in the immune system. T cells are responsible for recognizing and responding to foreign substances in the body, such as viruses and bacteria. When a T cell recognizes a foreign substance, it becomes activated and begins to divide and differentiate into a specialized type of cell called a T cell.

Trav9-1 is a type of protein that is expressed in T cells. It is made up of four chains of amino acids and has a unique structure that allows it to interact with other proteins in the T cell. This interaction is important for the function of the T cell, as it allows the T cell to communicate with other T cells and with the body's immune system in general.

One of the functions of Trav9-1 is to help the T cell recognize and respond to foreign substances. When a T cell encounters a foreign substance, such as a virus or a cancer cell, it becomes activated and begins to divide and differentiate into a specialized type of cell. This activation and differentiation process is critical for the immune system to protect the body against infection and disease.

Another function of Trav9-1 is to help the T cell communicate with other T cells and with the body's immune system. This interaction between Trav9-1 and other proteins is important for the regulation of the immune response, as it allows the T cells to communicate with each other and with the immune system and to coordinate their actions.

Trav9-1 is also involved in the regulation of the cell cycle. The cell cycle is the process by which cells grow, divide, and replicate themselves. Trav9-1 helps to control the length of the cell cycle, which is important for the proper functioning of the T cells.

In addition to its role in the immune system, Trav9-1 is also involved in the regulation of cell signaling pathways. Signaling pathways are the processes by which cells communicate with each other and with the surrounding environment. Trav9-1 is involved in the regulation of several signaling pathways, including theApoptosis (programmed cell death) pathway.

Trav9-1 is also a potential drug target. Researchers are interested in using Trav9-1 as a drug target because of its involvement in the immune system and cell signaling pathways. By targeting Trav9-1 with drugs, researchers hope to inhibit its function in these systems and to use this as a therapeutic approach for a variety of diseases.

In conclusion, Trav9-1 is a protein that is expressed in T cells and plays a crucial role in the immune system. It is involved in the regulation of the cell cycle and in the regulation of cell signaling pathways, and it is a potential drug target. Further research is needed to fully understand the role of Trav9-1 in the immune system and its potential as a drug.

Protein Name: T Cell Receptor Alpha Variable 9-1

Functions: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

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