KRTAP8-1 as A Potential Drug Target for Neurological Disorders

Target Name: KRTAP8-1

NCBI ID: G337879

KRTAP8-1

KRTAP8-1 as A Potential Drug Target for Neurological Disorders

KRTAP8-1 (OTTHUMP00000063454) is a protein that is expressed in the brain and is known for its role in the regulation of neural stem cells (NSCs) proliferation and differentiation. The protein is encoded by the KRTAP8 gene and has been shown to play a critical role in the development and maintenance of neural stem cells in the brain.

Recent studies have suggested that KRTAP8-1 may be a drug target or biomarker for various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. This is because the loss of KRTAP8-1 has been observed in the brains of individuals with these disorders, and compounds that can modulate KRTAP8-1 expression have been shown to be effective in treating these conditions.

One of the potential benefits of targeting KRTAP8-1 is that it has been shown to play a role in the development of neurodegenerative diseases. For example, studies have shown that individuals with the genetic mutation responsible for the development of Alzheimer's disease have lower levels of KRTAP8-1 in their brains compared to individuals without the mutation. Additionally, compounds that can increase KRTAP8-1 expression have been shown to be effective in animal models of Alzheimer's disease.

Another potential benefit of targeting KRTAP8-1 is its role in the regulation of neural stem cell proliferation and differentiation. KRTAP8-1 has been shown to play a critical role in the development and maintenance of NSCs, and compounds that can modulate KRTAP8-1 expression have been shown to affect the growth and differentiation of NSCs. This suggests that KRTAP8-1 may be a useful target for drugs that are aimed at promoting or inhibiting NSCs proliferation and differentiation.

In addition to its potential role in the development and maintenance of neural stem cells, KRTAP8-1 has also been shown to play a critical role in the regulation of neural circuit formation and function. Studies have shown that KRTAP8-1 is involved in the development of synaptic connections in the brain, and compounds that can modulate KRTAP8-1 expression have been shown to affect the strength and pattern of neural connections. This suggests that KRTAP8-1 may be a useful target for drugs that are aimed at modulating neural circuit formation and function.

Given the potential role of KRTAP8-1 in the development and maintenance of neural stem cells and neural circuit formation, it is an attractive target for drug development for a variety of neurological and psychiatric disorders. Further research is needed to fully understand the role of KRTAP8-1 in these processes and to identify compounds that can modulate its expression.

Protein Name: Keratin Associated Protein 8-1

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

The "KRTAP8-1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRTAP8-1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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