PPP1R3B: A Potential Drug Target and Biomarker for Protein Phosphatase 1

Target Name: PPP1R3B

NCBI ID: G79660

PPP1R3B

PPP1R3B: A Potential Drug Target and Biomarker for Protein Phosphatase 1

Introduction

Protein phosphorylation modification has important biological significance in organisms. It is a key step in various signal transduction pathways in organisms. However, abnormal phosphorylation modification levels may lead to various diseases, such as cancer, neurodegenerative diseases, etc. Therefore, it is of great clinical significance to study the regulatory mechanism of protein phosphorylation modification and reveal potential drug targets.

PPP1R3B, the full name of protein phosphorylation modification regulator 3B, is a protein expressed in a variety of cells. It plays a key role in a variety of biological processes, such as cell proliferation, apoptosis, cell cycle regulation, etc. At the same time, PPP1R3B also has the activity of inhibiting protein phosphorylation modification and negatively regulates a variety of proteins. This provides an important theoretical basis for studying the function of PPP1R3B, revealing its regulatory mechanism, and studying it as a drug target.

Domain analysis

PPP1R3B is a 280-amino-acid protein that contains a cytoplasmic domain, a transmembrane domain, and an intracellular domain. From the cytoplasmic region to the transmembrane region, PPP1R3B contains a hydrophobic N-terminal 伪-helix, which provides a stable space for protein and substrate binding. In the transmembrane region, PPP1R3B forms a 尾-sheet structure containing multiple conserved cysteine 鈥嬧?媟esidues. This domain is responsible for the negative regulation of substrate binding and phosphorylation modification of PPP1R3B.

In the intracellular region, PPP1R3B contains a special domain called the PDZ (phosphorylated-DNA-binding) domain. This domain has two functions: one is to bind to substrates and participate in the phosphorylation modification process; the other is to bind to DNA and may be involved in gene expression and regulation.

biological function analysis

PPP1R3B plays an important role in a variety of biological processes, such as cell cycle regulation, cell proliferation, apoptosis, etc. In cell cycle regulation, PPP1R3B participates in the progression of mitosis by inhibiting microtubule polymerization and spindle formation. During the process of cell proliferation, PPP1R3B participates in regulating cell cycle progression and negatively regulates the progression of cell proliferation. During the process of apoptosis, PPP1R3B participates in the process of apoptosis by regulating apoptosis signaling molecules on the cell membrane.

In addition, PPP1R3B plays an important role in immune response. Research shows that PPP1R3B plays a key role in the proliferation, differentiation and antigen recognition of T cells and B cells.

Drug target research

PPP1R3B has multiple biological functions and is therefore considered a potential drug target. Currently, researchers are exploring the role of PPP1R3B in tumors, neurodegenerative diseases and other diseases, and looking for related drugs.

1. Anti-tumor effect

PPP1R3B inhibitors can inhibit the proliferation, differentiation and metastasis of tumor cells. For example, studies have found that PPP1R3B inhibitors can significantly inhibit the invasion and metastasis of tumor cells. In addition, PPP1R3B inhibitors can also inhibit the angiogenesis of tumor cells, thus providing new ideas for combination therapy with anti-tumor drugs.

2. Neurodegenerative disease treatment

PPP1R3B plays an important role in neurodegenerative diseases. For example, PPP1R3B is involved in regulating neuronal apoptosis and is an important regulator of neuronal apoptosis. Therefore, PPP1R3B inhibitors can serve as potential therapeutic drugs for neurodegenerative diseases. Currently, researchers are exploring the application of PPP1R3B inhibitors in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

3. Immune response regulation

PPP1R3B plays an important role in immune response. Studies have shown that PPP1R3B can affect the proliferation, differentiation and antigen recognition processes of T cells and B cells. Therefore, PPP1R3B inhibitors can be used as a new immune response modulating drug. Currently, researchers are exploring the application of PPP1R3B inhibitors in autoimmune diseases, immune deficiency diseases, etc.

in conclusion

PPP1R3B plays an important role in a variety of biological processes and has potential as a drug target.

Protein Name: Protein Phosphatase 1 Regulatory Subunit 3B

Functions: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes (By similarity)

The "PPP1R3B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPP1R3B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
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•   related combination drugs;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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