PPP1R8: A Potential Drug Target and Biomarker (G5511)

Target Name: PPP1R8

NCBI ID: G5511

PPP1R8

PPP1R8: A Potential Drug Target and Biomarker

PPP1R8, also known as human PPP1R8, is a protein that is expressed in various tissues and cells throughout the body. It is a key regulator of the poly(ADP-ribose) polymerase (PARP) gene, which is involved in the repair of DNA damage.PARP is a transmembrane protein that contains a catalytic domain and a N-terminal region that is involved in the recognition of damaged DNA.PPP1R8 is a non-coding RNA molecule that functions as a scaffold to recruit PARP to the site of DNA damage.

The discovery of PPP1R8 as a potential drug target and biomarker has significant implications for the development of new treatments for a variety of diseases.Parathyroid hormone-related hyperparathyroidism (PTH) is a chronic autoimmune disorder that is characterized by the overproduction of parathyroid hormones.These hormones cause a significant increase in the levels of calcium in the blood, which can lead to a variety of symptoms, including bone pain, increased thirst, and decreased mobility.

PPP1R8 has been shown to play a role in the regulation of PARP and its function as a PARP scaffold.Several studies have shown that PPP1R8 levels are elevated in individuals with PTH, and that inhibiting its function as a PARP scaffold can reduce the production of parathyroid hormones.This suggests that PPP1R8 may be a useful target for the treatment of PTH.

In addition to its potential use as a drug target, PPP1R8 has also been shown to be a potential biomarker for PTH.Elevated PPP1R8 levels have been observed in individuals with PTH, and these levels have been used as a biomarker to diagnose the disease.Several studies have shown that individuals with PTH have lower levels of PPP1R8 than those without the disease.This suggests that PPP1R8 may be a useful biomarker for the diagnosis and monitoring of PTH.

The development of new treatments for PTH depends on the ability to identify individuals with the disease and to determine the effectiveness of any potential treatments. PPPs1R8 may be a valuable target for these efforts, as its function as a PARP scaffold suggests that it may be a useful target for the treatment of PTH.Further research is needed to determine the exact role of PPP1R8 in the treatment of PTH and to develop effective new treatments for this disease.

Protein Name: Protein Phosphatase 1 Regulatory Subunit 8

Functions: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation

The "PPP1R8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPP1R8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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