PPP1R7: A Potential Drug Target and Biomarker for Protein Phosphatase 1 Regulatory Subunit 22

Target Name: PPP1R7

NCBI ID: G5510

PPP1R7

Other Name(s): Protein phosphatase 1 regulatory subunit 22 | protein phosphatase 1 regulatory subunit 22 | Protein phosphatase 1 regulatory subunit 7 | protein phosphatase 1 regulatory subunit 7 | Protein phosphatase 1, regulatory (inhibitor) subunit 7 | Protein phosphatase-1 regulatory subunit 7 alpha2 | Protein phosphatase-1 regulatory subunit 7 beta2 | Protein phosphatase-1 regulatory subunit 7 beta1 | Protein phosphatase 1 regulatory subunit 7, transcript variant 1 | protein phosphatase 1, regulatory (inhibitor) subunit 7 | SDS22 | testis secretory sperm-binding protein Li 210a | Protein phosphatase 1 regulatory subunit 7 (isoform 1) | PPP1R7 variant 1 | PP1R7_HUMAN

PPP1R7: A Potential Drug Target and Biomarker for Protein Phosphatase 1 Regulatory Subunit 22

Protein phosphatase 1 (PP1) is an essential enzyme that regulates various cellular processes, including cell signaling, DNA replication, and protein synthesis. The protein encoded by the PPP1 regulatory subunit 22 (PP1R7) plays a crucial role in the regulation of PP1 activity. The dysfunction of PP1R7 has been implicated in various diseases, including cancer, neurodegenerative disorders, and developmental defects. As a result, targeting this protein has become an attractive research focus in recent years.

In this article, we will provide an overview of PPP1R7, including its structure, function, and potential as a drug target or biomarker. We will discuss the current understanding of PP1R7's role in cellular processes and the potential implications of targeting this protein for therapeutic intervention.

Structure and Function

PP1R7 is a 21 kDa protein that belongs to the PPR family 1. PPRs are a subclass of protein tyrosine phosphatases (PTPs), which include 16 different isoforms (1-16). PP1R7 is composed of a 191 amino acid residue protein and a 20 amino acid residue protein N-terminal tail.

PP1R7 functions as a negative regulator of PP1, which means that it inhibits the activity of PP1. This regulation is critical for maintaining cellular homeostasis, as PP1 plays a vital role in regulating various cellular processes, including cell signaling, DNA replication, and protein synthesis. The inhibition of PP1 by PP1R7 ensures that cells maintain a delicate balance between the production and degradation of signaling proteins, which are essential for cellular survival and growth.

Expression and Localization

PP1R7 is expressed in various cell types, including neurons, cardiac muscle cells, and cancer cells. The protein is predominantly nuclear, with a minor cytoplasmic expression. PP1R7 is predominantly localized to the endoplasmic reticulum (ER), where it can interact with PP1 and other regulatory proteins, including the transcription factor, p53.

PP1R7 has been shown to play a role in various cellular processes, including cell signaling, DNA replication, and protein synthesis. For example, PP1R7 has been shown to regulate the activity of the protein kinase, Aryl hydrocarbon receptor (AhR), which is involved in cell signaling. Additionally, PP1R7 has been shown to interact with the transcription factor, p53, and regulate its activity.

Drug Targeting and Biomarker

The potential drug targeting of PP1R7 is based on its role as a negative regulator of PP1. Drugs that can inhibit PP1R7 activity or enhance its stability can potentially be used to treat various diseases, including cancer, neurodegenerative disorders, and developmental defects.

One of the most promising drug targets for PP1R7 is the inhibition of its N-terminal region, which is known as the N-terminal hypervariable region (N-VHR). The N-VHR is a region of the protein that is highly variable and has been shown to play a role in various cellular processes. Drugs that can bind to the N-VHR and inhibit PP1R7 activity could be a useful therapeutic approach for the treatment of PP1-related diseases.

Another potential biomarker for PP1R7 is its expression level. As discussed above, PP1R7 is primarily expressed in the ER and has a limited cytoplasmic expression. Changes in PP1R7 expression levels could be an informative biomarker for the diagnosis and monitoring of various diseases, including cancer, neurodegenerative disorders, and developmental defects.

Conclusion

In conclusion, PPP1R7 is a protein that plays a critical role in the regulation of PP1 activity and is a potential drug target for the treatment of various diseases. The inhibition of PP1R7 activity or enhancement of its stability could be a valuable therapeutic approach for the treatment of PP1-related disorders. Further research is needed to fully understand the

Protein Name: Protein Phosphatase 1 Regulatory Subunit 7

Functions: Regulatory subunit of protein phosphatase 1

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