Unlocking the Potential of ATP6: A drug Target and Biomarker for treating various diseases

Target Name: ATP6

NCBI ID: G4508

ATP6

Unlocking the Potential of ATP6: A drug Target and Biomarker for treating various diseases

Introduction

ATP (adenosine triphosphate) is a crucial energy supplier for all living organisms. It is a small molecule that plays a vital role in biochemical reactions and signaling processes within cells. ATP releases energy through hydrolysis reactions, provides necessary energy for cells, and participates in a variety of biochemical reactions, including cell division, cell signaling, metabolic regulation, etc. ATP plays an important role in a variety of diseases and is therefore considered a potential drug target.

ATP6 is an ATPase that takes its name from its ability to catalyze the ATP hydrolysis reaction. ATP6 plays an important role in a variety of biochemical reactions, including metabolism, cell signaling, cell division, etc. The activity of ATP6 depends on specific chemical properties in its structure.

1. The significance of ATP6 in drug targets

1. Treat cancer

ATP6 is of great significance in the treatment of cancer. Many cancer cells rely on ATP6 for energy, so inhibiting ATP6 activity may be an effective cancer treatment. Some studies have shown that ATP6 inhibitors can inhibit the growth and spread of cancer cells and extend patient survival.

2. Treat neurodegenerative diseases

Neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, etc., are closely related to abnormal activation of ATP6. Activation of ATP6 leads to neuronal death and loss of neural tissue, therefore inhibiting ATP6 activity may be an effective treatment for neurodegenerative diseases.

3. Treat cardiovascular disease

ATP6 plays an important role in the cardiovascular system. Activation of ATP6 can regulate vasoconstriction and dilation, thereby affecting blood flow and blood pressure in the cardiovascular system. Therefore, inhibiting ATP6 activity may be an effective treatment for cardiovascular diseases.

2. Application of ATP6 as a biomarker

1. Detect tumors

As an important tumor indicator, ATP6 can be used to detect tumor growth and progression. Some studies have shown that the activity and amount of ATP6 can serve as indicators of tumor cells in tumor tissue. In addition, ATP6 can also be used as a monitor for tumor treatment, because inhibition of ATP6 can significantly inhibit tumor growth and spread.

2. Assessing Neurodegenerative Diseases

ATP6 serves as an important neurodegenerative disease indicator and can be used to evaluate the development and severity of the disease. Some studies have shown that ATP6 activity and amounts can serve as indicators of disease severity and disease progression in patients with neurodegenerative diseases. In addition, ATP6 could also be used as a monitor for the treatment of neurodegenerative diseases, as inhibition of ATP6 can significantly inhibit the progression and severity of the disease.

3. Assess for cardiovascular disease

As an important cardiovascular disease indicator, ATP6 can be used to evaluate the severity and progression of cardiovascular disease. Some studies have shown that ATP6 activity and quantity can serve as indicators of disease severity and disease progression in patients with cardiovascular disease. In addition, ATP6 can be used as a monitor for cardiovascular disease treatment, as inhibition of ATP6 can significantly inhibit the progression and severity of the disease.

3. Molecular mechanism of ATP6

1. Structure and function of ATP6

ATP6 is an ATPase that takes its name from its ability to catalyze the ATP hydrolysis reaction. ATP6 is composed of 12 different amino acids, including 4 acidic amino acids and 8 basic amino acids. The activity of ATP6 depends on specific chemical properties in its structure.

2. Enzymatic activity of ATP6

ATP6 is a very active enzyme that catalyzes the hydrolysis reaction of ATP. The catalytic activity of ATP6 is affected by many factors, including temperature, pH value and substrate concentration.

3. Substrate specificity of ATP6

ATP6 has different affinities for different substrates, which will affect its catalytic activity

Protein Name: Mitochondrially Encoded ATP Synthase 6

Functions: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane

The "ATP6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ATP6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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