PDE8A: A Potential Drug Target for Cell Signaling Pathways (G5151)

Target Name: PDE8A

NCBI ID: G5151

PDE8A

Other Name(s): Phosphodiesterase PDE8A | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (isoform 1) | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiestera

PDE8A: A Potential Drug Target for Cell Signaling Pathways

Phosphodiesterase PDE8A (PDE8A) is a protein that is expressed in various tissues and cell types in the human body. It plays a crucial role in the regulation of cell signaling pathways, including the signaling pathway that regulates cell growth, differentiation, and survival.

PDE8A is a member of the PDE family, which includes a variety of enzymes that regulate the phosphorylation of protein targets. These enzymes belong to the superfamily of phosphate hydrolase, and they are involved in the regulation of a wide range of cellular processes, including cell signaling, DNA replication, and protein transport.

PDE8A is a 120-kDa protein that is expressed in various tissues, including the brain, heart, kidney, and liver. It is primarily localized to the endoplasmic reticulum (ER), where it is involved in the degradation of various proteins, including Rab39, a protein that is involved in the regulation of cell signaling pathways.

PDE8A functions as a negative regulator of the signaling pathway that regulates cell growth, differentiation, and survival. This pathway is activated when the levels of cytosine DNA base in the cell are reduced, which triggers the G1 cell cycle checkpoint. At this point, PDE8A comes into play, as it facilitates the degradation of Rab39, which is required for the maintenance of the G1 cell cycle checkpoint.

PDE8A is also involved in the regulation of cell signaling pathways that are critical for cell survival. For example, PDE8A is involved in the regulation of the TGF-β signaling pathway, which is involved in the regulation of cell growth, differentiation, and survival.

In addition to its role in cell signaling pathways, PDE8A is also a potential drug target. Several studies have suggested that inhibiting PDE8A activity may be a useful way to treat a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

One of the reasons why PDE8A is considered a potential drug target is that it is involved in the regulation of a wide range of cellular processes, which makes it difficult to predict its effects on the cell. Additionally, PDE8A is a protein that is expressed in various tissues and cell types, which makes it difficult to target it with small molecules.

Another potential reason why PDE8A is a good drug target is that it is involved in the regulation of cell signaling pathways that are critical for human health. For example, PDE8A is involved in the regulation of the TGF-β signaling pathway, which is involved in the regulation of cell growth, differentiation, and survival. If PDE8A activity is inhibited, it is likely that the TGF-β signaling pathway will be activated, which could lead to the regulation of cell growth and survival.

PDE8A is also involved in the regulation of cell signaling pathways that are critical for the development and progression of cancer. For example, PDE8A is involved in the regulation of the p53 signaling pathway, which is involved in the regulation of cell growth and apoptosis. If PDE8A activity is inhibited, it is likely that the p53 signaling pathway will be activated, which could lead to the regulation of cell growth and apoptosis.

In conclusion, PDE8A is a protein that is involved in the regulation of various cellular processes, including cell signaling pathways that are critical for cell growth, differentiation, and survival. As a result, PDE8A is a potential drug target, and several studies have suggested that inhibiting PDE8A activity may be a useful way to treat a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Further research is needed to fully understand the role of PDE8A in cellular processes and to develop effective treatments.

Protein Name: Phosphodiesterase 8A

Functions: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299)

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•   general information;
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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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