PDGFD: A Potential Drug Target for Tissue Growth and Repair (G80310)

Target Name: PDGFD

NCBI ID: G80310

PDGFD

PDGFD: A Potential Drug Target for Tissue Growth and Repair

PDGFD (Platelet-derived growth factor D) is a protein that plays a crucial role in the development and maintenance of tissues, including blood vessels, muscles, and bones. It is a member of the growth factor family, which includes other well-known proteins such as PDGF-A, PDGF-B, and PDGF-BB. PDGFD is involved in several physiological processes in the body, including cell proliferation, differentiation, and angiogenesis.

PDGFD has been identified as a potential drug target and biomarker for several reasons. Firstly, PDGFD has been shown to promote the growth and survival of a variety of cell types, including platelets, which are important for blood clotting and healing. Secondly, PDGFD has been shown to play a role in the development and maintenance of tissues, including blood vessels, muscles, and bones. This makes it an attractive target for drugs that are designed to promote tissue growth and repair. Finally, PDGFD has been shown to be involved in several diseases, including cancer, which makes it an attractive target for drugs that can inhibit its activity.

One of the key challenges in studying PDGFD is its complex structure and biology. PDGFD is a 21-kDa protein that consists of a transmembrane domain and an extracellular domain. The transmembrane domain is involved in the formation of PDGFD dimers, which are important for its biological activity. The extracellular domain is involved in the interaction between PDGFD and its downstream targets.

PDGFD has been shown to play a role in several physiological processes in the body. For example, it has been shown to promote the growth and survival of platelets, which are important for blood clotting and healing. PDGFD has also been shown to play a role in the development and maintenance of tissues, including blood vessels, muscles, and bones. This makes it an attractive target for drugs that are designed to promote tissue growth and repair.

PDGFD has been shown to be involved in several diseases, including cancer. For example, it has been shown to promote the growth and survival of cancer cells. This makes it an attractive target for drugs that can inhibit its activity. One of the most promising strategies for targeting PDGFD is the use of small molecules, such as drugs that can inhibit the activity of PDGFD dimers.

In conclusion, PDGFD is a protein that plays a crucial role in the development and maintenance of tissues, including blood vessels, muscles, and bones. It is a potential drug target and biomarker due to its involvement in several physiological processes in the body and its association with several diseases. Further research is needed to fully understand its biology and develop effective treatments.

Protein Name: Platelet Derived Growth Factor D

Functions: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity)

The "PDGFD Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PDGFD comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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