PDGFRB: A Potential Drug Target and Biomarker for Various Diseases

Target Name: PDGFRB

NCBI ID: G5159

PDGFRB

PDGFRB: A Potential Drug Target and Biomarker for Various Diseases

PDGFRB (Platelet-Derived Growth Factor Receptor, Beta Polypeptide) is a protein that is expressed in various tissues of the body, including blood platelets, endothelial cells, and epithelial cells. It plays a crucial role in cell signaling, particularly in the regulation of cell proliferation and survival. PDGFRB has also been identified as a potential drug target and biomarker for various diseases, including cancer, cardiovascular disease, and neurological disorders.

PDGFRB is a member of the tyrosine kinase family, which includes several well-known proteins, including PDGF1, PDGF2, PDGF4, and PDGF7. These proteins are involved in the regulation of cell growth, differentiation, and survival, and are often involved in the development and progression of various diseases. PDGFRB is specifically involved in the regulation of cell proliferation and survival, and has been shown to play a role in the regulation of cell cycle progression, apoptosis, and angiogenesis.

PDGFRB has been shown to be involved in the regulation of cell proliferation and survival in various tissues of the body. For example, studies have shown that PDGFRB is involved in the regulation of cell proliferation in various types of cancer, including breast, lung, and colon cancer. PDGFRB has also been shown to be involved in the regulation of cell apoptosis, which is the process by which cells die as a result of various factors, including DNA damage, UV radiation, and chemotherapy. In addition, PDGFRB has been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels form in the body.

PDGFRB has also been shown to be involved in the regulation of cellular signaling pathways that are important for the development and progression of various diseases. For example, studies have shown that PDGFRB is involved in the regulation of the PI3K/Akt signaling pathway, which is involved in the regulation of cell survival and angiogenesis. Additionally, PDGFRB is involved in the regulation of the TGF-β signaling pathway, which is involved in the regulation of cell growth, differentiation, and survival.

PDGFRB has also been shown to be involved in the regulation of cellular signaling pathways that are important for the development and progression of various neurological disorders. For example, studies have shown that PDGFRB is involved in the regulation of the neurotrophin signaling pathway, which is involved in the regulation of neurotransmitter release and neuroprotection. Additionally, PDGFRB is involved in the regulation of the PDGF receptor signaling pathway, which is involved in the regulation of cell proliferation and survival.

In addition to its role in cell signaling, PDGFRB has also been shown to be involved in the regulation of cellular processes that are important for the development and progression of various diseases. For example, studies have shown that PDGFRB is involved in the regulation of cell migration, which is the movement of cells from one location to another in the body. Additionally, PDGFRB is involved in the regulation of cell adhesion, which is the process by which cells stick together and form tissues.

PDGFRB has also been shown to be involved in the regulation of cellular signaling pathways that are important for the development and progression of various cardiovascular diseases. For example, studies have shown that PDGFRB is involved in the regulation of the angiogenesis signaling pathway, which is involved in the regulation of new blood vessel formation in the body. Additionally, PDGFRB is involved in the regulation of cell proliferation and survival in various types of cardiovascular disease, including heart failure, hypertension, and myocardial infarction.

In conclusion, PDGFRB is a protein that is involved in the regulation of cell signaling, cell cycle progression, apoptosis, angiogenesis, and cellular processes that are important for the development and progression of various diseases. As a potential drug target and biomarker, PDGFRB is an attractive target for

Protein Name: Platelet Derived Growth Factor Receptor Beta

Functions: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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