Understanding Zinc Finger (ZDHHC7): Potential Drug Target Or Biomarker
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Understanding Zinc Finger (ZDHHC7): Potential Drug Target Or Biomarker
Zinc Finger (ZDHHC7), also known as Zinc finger protein 7, is a protein that is expressed in various tissues throughout the body. It is a member of the DHHC family, which includes proteins that contain a zinc finger domain. The ZDHHC7 protein is of particular interest as it has been shown to be involved in a number of cellular processes, including cell signaling, DNA replication, and metabolism.
The ZDHHC7 protein is composed of 21 amino acid residues and has a calculated molecular weight of 21.9 kDa. It is expressed in a variety of tissues, including muscle, liver, and brain. It is also found in the cytoplasm of cells and can be visualized using techniques such as immunofluorescence or protein array.
One of the most interesting aspects of the ZDHHC7 protein is its zinc finger domain. This domain is composed of four amino acids: ZN, F, H, and C. The ZN finger is a common structural element that is found in many proteins and is responsible for protein-protein interactions. The F finger is a specific type of zinc finger that is involved in the formation of a protein-protein complex. The H finger is a structural element that is often found in proteins that is involved in the regulation of gene expression. The C finger is a structural element that is commonly found in proteins and is involved in the formation of a protein-protein complex.
The ZDHHC7 protein is involved in a number of cellular processes, including cell signaling, DNA replication, and metabolism. For example, the ZDHHC7 protein has been shown to be involved in the regulation of cell proliferation. Studies have shown that the ZDHHC7 protein can inhibit the growth of cancer cells and may be a potential drug target for cancer treatment.
The ZDHHC7 protein is also involved in the regulation of DNA replication. Studies have shown that the ZDHHC7 protein can inhibit the activity of the DNA replication factor, RPA1, which is responsible for repairing damaged DNA. This may have implications for the treatment of genetic disorders such as DNA damage-induced cancers.
The ZDHHC7 protein is also involved in metabolism. Studies have shown that the ZDHHC7 protein can modulate the activity of the enzymes responsible for glucose metabolism and lipid metabolism. This may have implications for the treatment of diseases such as diabetes and obesity.
In conclusion, Zinc Finger (ZDHHC7) is a protein that is of particular interest as it has been shown to be involved in a number of cellular processes. The ZDHHC7 protein is expressed in various tissues and can be visualized using techniques such as immunofluorescence or protein array. The ZDHHC7 protein's zinc finger domain, as well as its involvement in cell signaling, DNA replication, and metabolism, make it a potential drug target or biomarker. Further research is needed to fully understand the role of the ZDHHC7 protein in cellular processes and its potential as a drug target or biomarker.
Protein Name: Zinc Finger DHHC-type Palmitoyltransferase 7
Functions: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (PubMed:22031296, PubMed:27380321, PubMed:28196865). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways (PubMed:19001095). Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane (PubMed:25301068). In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation (PubMed:27380321). Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration (PubMed:28196865). Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane (By similarity). In brain, could also palmitoylate SNAP25 and DLG4/PSD95 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate NCDN (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity)
The "ZDHHC7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZDHHC7 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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ZDHHC8 | ZDHHC8BP | ZDHHC9 | ZEB1 | ZEB1-AS1 | ZEB2 | ZEB2-AS1 | ZER1 | ZFAND1 | ZFAND2A | ZFAND2B | ZFAND3 | ZFAND4 | ZFAND5 | ZFAND6 | ZFAS1 | ZFAT | ZFAT-AS1 | ZFC3H1 | ZFHX2 | ZFHX3 | ZFHX4 | ZFHX4-AS1 | ZFP1 | ZFP14 | ZFP2 | ZFP28 | ZFP28-DT | ZFP3 | ZFP30 | ZFP36 | ZFP36L1 | ZFP36L2 | ZFP37 | ZFP41 | ZFP42 | ZFP57 | ZFP62 | ZFP64 | ZFP64P1 | ZFP69 | ZFP69B | ZFP82 | ZFP90 | ZFP91 | ZFP91-CNTF | ZFP92 | ZFPL1 | ZFPM1 | ZFPM2 | ZFPM2-AS1 | ZFR | ZFR2 | ZFTA | ZFTRAF1 | ZFX | ZFX-AS1 | ZFY | ZFYVE1 | ZFYVE16 | ZFYVE19 | ZFYVE21 | ZFYVE26 | ZFYVE27 | ZFYVE28 | ZFYVE9 | ZFYVE9P1 | ZG16 | ZG16B | ZGLP1 | ZGPAT | ZGRF1 | ZHX1 | ZHX1-C8orf76 | ZHX2 | ZHX3 | ZIC1 | ZIC2 | ZIC3 | ZIC4 | ZIC5 | ZIK1 | ZIM2 | ZIM3 | Zinc finger protein GLI | ZKSCAN1 | ZKSCAN2 | ZKSCAN3 | ZKSCAN4 | ZKSCAN5 | ZKSCAN7 | ZKSCAN8 | ZKSCAN8P1 | ZMAT1 | ZMAT2 | ZMAT3 | ZMAT4 | ZMAT5 | ZMIZ1 | ZMIZ1-AS1