CACNG7: A Calcium-Regulated Channels for Neurotransmitter Signaling and Psychiatric Disorders

Target Name: CACNG7

NCBI ID: G59284

CACNG7

Other Name(s): Calcium voltage-gated channel auxiliary subunit gamma 7, transcript variant 1 | neuronal voltage-gated calcium channel gamma-7 subunit | Transmembrane AMPAR regulatory protein gamma-7 | Voltage-dependent calcium channel gamma-7 subunit | TARP gamma-7 | transmembrane AMPAR regulatory protein gamma-7 | calcium voltage-gated channel auxiliary subunit gamma 7 | calcium channel, voltage-dependent, gamma subunit 7 | CCG7_HUMAN | CACNG7 variant 1 | Voltage-dependent calcium channel gamma-7 subunit (isoform 1) | Neuronal voltage-gated calcium channel gamma-7 subunit

CACNG7: A Calcium-Regulated Channels for Neurotransmitter Signaling and Psychiatric Disorders

Introduction

CACNG7, or calcium-regulated auxiliary subunit G7, is a highly conserved transmembrane protein that plays a critical role in neurotransmitter signaling. It is expressed in high levels in the central nervous system (CNS) and is involved in the regulation of action potentials, synaptic plasticity, and neurotransmitter release. The dysregulation of CACNG7 has been implicated in various psychiatric disorders, including epilepsy, schizophrenia, and mood disorders. As a result, CACNG7 has emerged as a promising drug target and a biomarker for these disorders.

CACNG7 Localizes to the Endoplasmic Reticulum and Recyclin

CACNG7 is a type-I transmembrane protein that is expressed in the endoplasmic reticulum (ER) and is involved in the recycling of its subunits. The ER is a protein synthesis machine that removes proteins from the cell surface and delivers them to the cytoplasm for further processing or degradation. The ER is a dynamic organ that forms the boundary between the cytoplasm and the nucleus and is responsible for maintaining the stability of the cell. The recyclein family of proteins, which includes CACNG7, plays a crucial role in ER-to- cytoplasmic protein transport by facilitating the delivery of proteins to the cytoplasm.

CACNG7 Regulates Neurotransmitter Release and Synaptic Transmission

CACNG7 is involved in the regulation of neurotransmitter release and synaptic transmission, which are critical processes that underlie neuronal communication. Neurotransmitters are released from the axon terminal of neurons and act on receptors located in the dendrites to transmit signals to other neurons. The release of neurotransmitters is regulated by various factors, including the levels of neurotransmitter synthesis, the duration of synaptic transmission, and the strength of the synaptic transmission.

CACNG7 is involved in the regulation of neurotransmitter release by controlling the activity of voltage-gated channels, which are critical for the release of neurotransmitters. Calcium ions are essential for neurotransmitter release and are involved in the regulation of many cellular processes, including neurotransmitter release ( 2). The voltage-gated channels, which are expressed in high levels in the CNS, are involved in the regulation of the influx of calcium ions into the cells.

CACNG7 is also involved in the regulation of synaptic transmission by controlling the release of neurotransmitter-containing vesicles from the axon terminal. The vesicles are the structures that store neurotransmitters and are released from the axon terminal in response to changes in the levels of neurotransmitter synthesis and the strength of the synaptic transmission. The release of vesicles from the axon terminal is regulated by various factors, including the levels of neurotransmitter synthesis, the duration of synaptic transmission, and the strength of the synaptic transmission.

CACNG7 and psychiatric disorders

The dysregulation of CACNG7 has been implicated in various psychiatric disorders, including epilepsy, schizophrenia, and mood disorders. Epilepsy, or epilepsy, is a chronic electrical disorder that is characterized by the rapid and recurrent discharge of neurons in the CNS. The exact cause of epilepsy is not known, but it is thought to involve the dysregulation of various signaling pathways, including the regulation of neurotransmitter release and synaptic transmission.

CACNG7 has been implicated in the regulation of neurotransmitter release in epilepsy by controlling

Protein Name: Calcium Voltage-gated Channel Auxiliary Subunit Gamma 7

Functions: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed:21127204). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2 (PubMed:21172611)

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