Target Name: UQCRC1
NCBI ID: G7384
Review Report on UQCRC1 Target / Biomarker Content of Review Report on UQCRC1 Target / Biomarker
UQCRC1
Other Name(s): complex III subunit 1 | ubiquinol-cytochrome c reductase core protein I | Ubiquinol-cytochrome-c reductase complex core protein 1 | UQCR1 | ubiquinol-cytochrome c reductase core protein 1 | ubiquinol-cytochrome-c reductase complex core protein 1 | D3S3191 | core protein I | PKNPY | Cytochrome b-c1 complex subunit 1, mitochondrial | QCR1 | QCR1_HUMAN | Core protein I | Ubiquinol-cytochrome c reductase core protein 1 | Complex III subunit 1

Targeting UQCRC1 for Drug Development

UQCRC1 (Complex III Subunit 1) is a protein that is expressed in various tissues throughout the body, including the brain, heart, kidneys, and liver. Its function is not well understood, but it is known to be involved in a number of cellular processes that are important for maintaining tissue health and homeostasis.

One of the key functions of UQCRC1 is its role in the regulation of ion channels, which are critical for the flow of electrical signals through cells. UQCRC1 is known to be involved in the regulation of the potassium (K+) and sodium (Na+) channels , which are important for a variety of physiological processes, including muscle and nerve function, as well as the regulation of the heartbeat.

In addition to its role in ion channel regulation, UQCRC1 is also known to be involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues and organs. This is an important process that is critical for the development and maintenance of tissues, and is also implicated in a number of diseases, including cancer.

UQCRC1 is also known to be involved in the regulation of cell signaling pathways, which are the processes by which cells communicate with one another to control a variety of cellular processes. This is an important function of UQCRC1, as it allows cells to respond to a wide range of stimuli, including changes in the concentration of ions in the body.

Another function of UQCRC1 is its role in the regulation of protein synthesis, which is the process by which cells produce the proteins that are essential for many cellular processes. This is an important function of UQCRC1, as it allows cells to produce the proteins that are necessary for maintaining tissue health and homeostasis.

In addition to its role in regulation of ion channels, cell adhesion, and protein synthesis, UQCRC1 is also known to be involved in the regulation of a variety of other cellular processes, including the regulation of cell growth, apoptosis (programmed cell death), and inflammation.

Given its involvement in a wide range of cellular processes, UQCRC1 is an attractive drug target for researchers who are interested in developing new treatments for a variety of diseases. In particular, UQCRC1 is an attractive target for diseases that are characterized by the disruption of ion channels and the regulation of cell signaling pathways.

One potential approach to targeting UQCRC1 is to use small molecules that can modulate its activity. For example, researchers might try using drugs that can bind to UQCRC1 and disrupt its function in the regulation of ion channels and cell signaling pathways.

Another potential approach to targeting UQCRC1 is to use antibodies that can recognize and target UQCRC1. This would allow researchers to study the effects of UQCRC1 on cellular processes, and could potentially lead to the development of new treatments for a variety of diseases.

Overall, UQCRC1 is a protein that is involved in a wide range of cellular processes that are important for maintaining tissue health and homeostasis. As such, it is an attractive drug target for researchers who are interested in developing new treatments for a variety of diseases. Further research is needed to fully understand the functions of UQCRC1 and to develop effective treatments based on this protein.

Protein Name: Ubiquinol-cytochrome C Reductase Core Protein 1

Functions: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons (PubMed:33141179)

The "UQCRC1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UQCRC1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

UQCRC2 | UQCRC2P1 | UQCRFS1 | UQCRFS1P1 | UQCRH | UQCRHL | UQCRQ | URAD | URAHP | URB1 | URB1-AS1 | URB2 | Urea transporter | URGCP | URGCP-MRPS24 | URI1 | Uridine phosphorylase | URM1 | UROC1 | UROD | UROS | USB1 | USE1 | USF1 | USF2 | USF3 | USH1C | USH1G | USH2A | USHBP1 | USO1 | USP1 | USP1-UAF1 complex | USP10 | USP11 | USP12 | USP12-AS1 | USP12-DT | USP13 | USP14 | USP15 | USP16 | USP17L1 | USP17L10 | USP17L11 | USP17L12 | USP17L13 | USP17L14P | USP17L15 | USP17L17 | USP17L18 | USP17L2 | USP17L20 | USP17L21 | USP17L24 | USP17L25 | USP17L26 | USP17L27 | USP17L29 | USP17L3 | USP17L5 | USP17L6P | USP17L7 | USP17L8 | USP17L9P | USP18 | USP19 | USP2 | USP2-AS1 | USP20 | USP21 | USP22 | USP24 | USP25 | USP26 | USP27X | USP27X-DT | USP28 | USP29 | USP3 | USP3-AS1 | USP30 | USP30-AS1 | USP31 | USP32 | USP32P1 | USP32P2 | USP32P3 | USP33 | USP34 | USP35 | USP36 | USP37 | USP38 | USP39 | USP4 | USP40 | USP41 | USP42 | USP43