Target Name: RNF128
NCBI ID: G79589
Review Report on RNF128 Target / Biomarker Content of Review Report on RNF128 Target / Biomarker
RNF128
Other Name(s): RN128_HUMAN | gene related to anergy in lymphocytes protein | ring finger protein 128 | ring finger protein 128, E3 ubiquitin protein ligase | E3 ubiquitin-protein ligase RNF128 | RNF128 variant 1 | E3 ubiquitin-protein ligase RNF128 (isoform 2) | RNF128 variant 2 | Ring finger protein 128, transcript variant 1 | GRAIL | Ring finger protein 128, transcript variant 2 | Gene related to anergy in lymphocytes protein | RING-type E3 ubiquitin transferase RNF128 | RING finger protein 128 | E3 ubiquitin-protein ligase RNF128 (isoform 1)

Modulating HRNA-RNP Complex with Curcumin and Resveratrol

RNA-Nucleic Acid (RNA) fold proteins are a family of non-coding RNAs that play a crucial role in various cellular processes. One of the best-known RNA-folds is the nucleolar RNA-fold (RNP), which is composed of a core-伪 helix and a 尾-sheet. The RNA-Nucleic Acid (RNA-NA) fold is a subclass of the RNP, characterized by the presence of a 10-mer loop region in the central region of the 尾-sheet.

One of the most well-studied RNA-folds is the nucleolus-related RNA-fold (RrN), which is a subclass of the RNA-NA fold that is found in the nuclei of eukaryotic cells. The RrN is composed of a 16- mer loop region that is similar to the 尾-sheet of the RNP, but it is connected to the 尾-sheet by a 10-mer alpha-helical arm. The RrN is also known as the small nuclear RNA (snRNA) gene 1 ( RNA-NA-1) or as housekeeping RNA (HRNA).

HRNA is a non-coding RNA molecule that plays a variety of roles in various cellular processes, including the regulation of gene expression, DNA replication, and repair, and cell signaling. HRNA is derived from the pre-mRNA molecule through a process called splicing , in which the intron regions are removed and the exon regions are connected to create a final RNA molecule. HRNA can be either sense or anti-sense, meaning that the orientation of the amino acids in the protein is either in the same order as the reference sequence or in the opposite order.

HRNA has been identified as a potential drug target in various diseases, including cancer, cardiovascular disease, and neurological disorders. One of the main reasons for this is the high level of expression of HRNA in various tissues and organs, which makes them difficult to target with small molecules. In addition, the complexity of HRNA structure and function, as well as the difficulty of modifying HRNA, makes it challenging to develop small molecules that can specifically target HRNA without also affecting other RNA molecules.

One approach to targeting HRNA is to use small molecules that can modulate the activity of HRNA-RNP complex, which is the complex between HRNA and the RNA-NA fold. The RNA-NA fold is a key component of the HRNA-RNP complex, and modulating its activity can have a profound impact on the function of HRNA.

One of the most well-known small molecules that can modulate the activity of HRNA-RNP complex is curcumin, which is an alkaline-endowed plant compound that is commonly used as a dietary supplement. Curcumin has been shown to have a variety of biological effects , including the regulation of gene expression, DNA replication, and repair, and the inhibition of protein-protein interactions. In addition, curcumin has been shown to modulate the activity of HRNA-RNP complex by binding to the RNA-NA fold and interacting with the carboxylic acid residues on the HRNA.

Other small molecules that have been shown to be effective in modulating the activity of HRNA-RNP complex include resveratrol, a natural product derived from red wine, and quercetin, a flavonoid found in a variety of fruits and vegetables. Resveratrol and quercetin have been shown to inhibit the activity of the protein-protein interaction between the HRNA and the RNA-NA fold, as well as the activity of a protein called RNA-protein interaction repressor (RPIM), which is involved in the regulation of HRNA expression.

While small molecules have shown promise in modulating the activity of HRNA-RNP complex, there are still many challenges that must be addressed before they can be effectively used as drugs. First, the exact mechanism of action of small molecules on HRNA-RNP complex is not well understood, which makes it difficult to predict their efficacy. Second, the

Protein Name: Ring Finger Protein 128

Functions: E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals

The "RNF128 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNF128 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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