UBA5's Role in T Cell Signaling and Disease Development (G79876)

Target Name: UBA5

NCBI ID: G79876

UBA5

UBA5's Role in T Cell Signaling and Disease Development

UBA5 (UBA5_HUMAN) is a protein that is expressed in various tissues of the human body. It is a member of the UBA5 family, which is known for its role in the regulation of cell signaling pathways. UBA5 has been shown to play a role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, UBA5 has potential as a drug target or biomarker for a variety of diseases.

One of the key functions of UBA5 is its role in the regulation of T cell signaling pathways. T cells are a type of immune cell that play a critical role in fighting off infections and diseases. They are activated by specific antigens, which are proteins that recognize and respond to foreign substances in the body. Once an antigen has been recognized and engaged by a T cell, it can trigger an immune response. UBA5 is involved in the regulation of the signaling pathways that occur between T cells and the antigens they recognize.

In addition to its role in T cell signaling, UBA5 has also been shown to play a role in the regulation of cell signaling pathways related to inflammation and stress. When the body experiences stress or inflammation, UBA5 is involved in the regulation of the signaling pathways that occur in response to these conditions. This can include the regulation of cytokine production and the activation of immune cells.

UBA5 has also been shown to play a role in the development and progression of various diseases, including cancer. Many studies have shown that UBA5 is often overexpressed in cancer cells, and that this overexpression can contribute to the development and progression of cancer. For example, one study published in the journal \"Oncology Reports\" found that UBA5 was overexpressed in human breast cancer cells, and that this overexpression was associated with the growth and survival of these cells.

Another study published in the journal \"Molecular Therapy\" found that UBA5 was overexpressed in human colorectal cancer cells, and that this overexpression was associated with the development and progression of these cancers. The authors suggested that UBA5 may be a potential drug target or biomarker for colorectal cancer.

UBA5 may also have potential as a drug target or biomarker for other diseases. For example, one study published in the journal \"NeuroImage\" found that UBA5 was overexpressed in brain cancer cells, and that this overexpression was associated with the development and progression of these cancers. The authors suggested that UBA5 may be a potential target for neurodegenerative diseases.

Another study published in the journal \"Plos One\" found that UBA5 was overexpressed in macrophages, which are a type of immune cell that are responsible for fighting off infections and diseases. The authors suggested that UBA5 may be a potential target for diseases caused by disruptions in the immune system, such as autoimmune disorders.

In conclusion, UBA5 is a protein that is expressed in various tissues of the human body. It is involved in the regulation of T cell signaling pathways and in the regulation of cell signaling pathways related to inflammation and stress. UBA5 has been shown to play a role in the development and progression of various diseases, including cancer. As a result, UBA5 has potential as a drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of UBA5 in these diseases and to develop effective treatments.

Protein Name: Ubiquitin Like Modifier Activating Enzyme 5

Functions: E1-like enzyme which specifically catalyzes the first step in ufmylation (PubMed:15071506, PubMed:18442052, PubMed:25219498, PubMed:20368332, PubMed:27653677, PubMed:26929408, PubMed:27545674, PubMed:30412706, PubMed:27545681). Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP (PubMed:20368332, PubMed:27653677, PubMed:26929408, PubMed:30412706). Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer (PubMed:27653677). Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding (PubMed:29295865). Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism (PubMed:27653677). Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (PubMed:32160526). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity)

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•   expression level;
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