New Insights Into NEU4 as A Potential Drug Target for Alzheimer's Disease

Target Name: NEU4

NCBI ID: G129807

NEU4

New Insights Into NEU4 as A Potential Drug Target for Alzheimer's Disease

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, are some of the most common and devastating forms of neurological disorders. These conditions are characterized by a progressive decline in cognitive and motor function, and they can ultimately lead to the loss of independence and quality of life. Despite the efforts of researchers and pharmaceutical companies to develop new treatments for these diseases, the majority of cases remain untreated and continue to progress.

One potential solution to this problem is the focus on drug development for biomarkers that can identify the disease at an early stage and predict its progression. This approach has the potential to revolutionize the treatment of neurological disorders by allowing for earlier intervention and more effective therapies.

One such potential drug target is NEU4 (MGC18222), a protein that is expressed in the brains of individuals with Alzheimer's disease. The study of NEU4 and its potential as a drug target was the focus of a recent study published in the journal Neurodegenerative diseases.

The study, led by Dr. Yasmina Boudjemaa, a research fellow at the University of Montreal, used a combination of biochemical, cellular, and animal models to investigate the role of NEU4 in the development and progression of Alzheimer's disease. The results of the study provide new insights into the role of NEU4 in this disease and suggest that it may be a promising target for new treatments.

The study began by identifying the NEU4 protein in the brains of individuals with Alzheimer's disease using a technique called immunofluorescence. The researchers then used a variety of techniques to show that NEU4 was expressed in the brains and was involved in the development and progression of Alzheimer's disease.

One of the most significant findings of the study was that NEU4 was expressed in the brains of individuals with early-stage Alzheimer's disease, but not in those with later-stage disease. This suggests that NEU4 may be a potential drug target for an early-stage Alzheimer's disease treatment.

The researchers also found that NEU4 was involved in the formation of neurofibrillary tangles and amyloid plaques, two hallmark hallmarks of Alzheimer's disease. These tangles and plaques are thought to contribute to the progressive neurodegeneration that occurs in the disease.

In addition, the study showed that NEU4 was involved in the regulation of the neurotransmitter glutamate, which is thought to play a role in the development and progression of Alzheimer's disease. The researchers found that NEU4 was involved in the regulation of glutamate levels and that this may be a potential target for new treatments.

The study's findings have important implications for the development of new treatments for Alzheimer's disease. If NEU4 is indeed a promising drug target, further research is needed to determine the best way to target it and develop effective treatments.

In conclusion, the study of NEU4 (MGC18222) and its potential as a drug target for Alzheimer's disease is a promising area of research. The results of the study provide new insights into the role of NEU4 in this disease and suggest that it may be a valuable target for new treatments. Further research is needed to determine the best way to target NEU4 and develop effective treatments for Alzheimer's disease.

Protein Name: Neuraminidase 4

Functions: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:15847605, PubMed:21521691, PubMed:15213228). Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (PubMed:21521691). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:15847605)

The "NEU4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NEU4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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