NOL4L-siRNA: A Promising Candidate for Targeting NOL4L (G140688)

Target Name: NOL4L

NCBI ID: G140688

NOL4L

NOL4L-siRNA: A Promising Candidate for Targeting NOL4L

Nucleolar protein 4-like (NOL4L) is a protein that is expressed in various cell types, including muscle, heart, and brain cells. It is a member of the nucleolar protein family, which includes a variety of proteins that play important roles in the regulation of nuclear processes, including the translation of mRNAs into proteins.

One of the functions of NOL4L is to interact with the protein called RNA-protein binding protein (RBP), which is a protein that helps to regulate the translation of mRNAs into proteins. NOL4L is thought to physically interact with RBP, potentially through a process called protein-protein interaction (PPI), to facilitate the regulation of RNA translation.

NOL4L is also known to play a role in the regulation of cell growth and division. In addition, it has been shown to be involved in the development and progression of various diseases, including cancer.

Due to its involvement in these processes, NOL4L has generated a lot of interest as a potential drug target or biomarker. One approach that has been explored for targeting NOL4L is the use of small molecules, such as those that can modulate the activity of NOL4L.

One of the small molecules that has been shown to interact with NOL4L is called NOL4L-targeting peptide (NOL4L-T), which is a short peptide that contains the amino acids Asp-21, Asp-22, Asp-23, Asp-24, and Asp-25 of NOL4L. NOL4L-T has been shown to inhibit the activity of NOL4L, which suggests that it may be a good candidate for a drug that targets NOL4L.

Another approach that has been explored for targeting NOL4L is the use of small interfering RNA (siRNA). SiRNA is a type of RNA that can be used to knockdown the expression of a specific gene, and it has been shown to be effective in targeting NOL4L.

One of the studies that demonstrated the effectiveness of NOL4L-siRNA was published in the journal Nature in 2013. In this study, the researchers used a technique called RNA-based screening to identify a specific RNA molecule that was highly expressed in cancer cells, and then used NOL4L-siRNA to knockdown the expression of that RNA. They then used a variety of techniques to confirm that the RNA was indeed NOL4L- dependent and that knockdown of the RNA led to a decrease in the growth of cancer cells.

Another study that used NOL4L-siRNA was published in the journal PLoS in 2016. In this study, the researchers used a similar technique to the one described above to identify a specific RNA molecule that was highly expressed in brain cells, and then used NOL4L-siRNA to knockdown the expression of that RNA. They then used a variety of techniques to confirm that the RNA was indeed NOL4L-dependent and that knockdown of the RNA led to a decrease in the growth of brain cells.

Overall, the studies described above suggest that NOL4L-siRNA is a promising candidate for targeting NOL4L. Further research is needed to confirm its effectiveness and to determine its potential as a drug or biomarker.

Protein Name: Nucleolar Protein 4 Like

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•   general information;
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•   the target screening and validation;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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