Nucleolar Protein 8 as A Potential Drug Target and Biomarker (G55035)

Target Name: NOL8

NCBI ID: G55035

NOL8

Nucleolar Protein 8 as A Potential Drug Target and Biomarker

Nucleolar protein 8 (NOL8) is a protein that is expressed in all types of cells in the body. It is a key component of the nucleolus, which is the functional unit of the cell where DNA is replicated and RNA is synthesized. NOL8 plays a crucial role in the regulation of cell growth, cell division, and RNA metabolism.

Recent studies have identified NOL8 as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and mental health conditions. NOL8 has also been shown to be involved in the development and progression of certain diseases, which could make it an attractive target for drug development.

One of the key reasons for the potential of NOL8 as a drug target is its involvement in the regulation of cell growth and cell division. NOL8 has been shown to play a role in the regulation of cell cycle progression, including the G1/S transition, which is the stage of cell growth where the cell prepares for cell division.

Research has shown that NOL8 promotes the G1/S transition by interacting with the protein kinase p21, which is a key regulator of the cell cycle. NOL8 has also been shown to inhibit the activity of the oncogene badp3, which promotes the growth and survival of cancer cells.

In addition to its role in cell growth and cell division, NOL8 has also been shown to play a role in the regulation of RNA metabolism. NOL8 is a transcription factor that has been shown to interact with the RNA polymerase II, which is responsible for synthesizing RNA from DNA.

Research has shown that NOL8 plays a role in the regulation of gene expression by binding to specific DNA sequences and regulating the activity of the RNA polymerase II. This suggests that NOL8 may be a useful target for drugs that are designed to inhibit or enhance RNA synthesis.

The potential of NOL8 as a drug target is further enhanced by its involvement in the development and progression of certain diseases. For example, studies have shown that NOL8 is expressed in the majority of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

In addition, NOL8 has also been shown to be involved in the development of certain mental health conditions, such as depression and anxiety. This suggests that NOL8 may be a potential target for drugs that are designed to treat these conditions.

Overall, NOL8 is a protein that has the potential to be a drug target and biomarker for a wide range of diseases. Further research is needed to fully understand its role in cell growth, cell division, and RNA metabolism, as well as its involvement in the development and progression of disease.

Protein Name: Nucleolar Protein 8

Functions: Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells

The "NOL8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NOL8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets