PRIMA1: A Potential Drug Target and Biomarker (G145270)

Target Name: PRIMA1

NCBI ID: G145270

PRIMA1

PRIMA1: A Potential Drug Target and Biomarker

PRIMA1 (Proline-rich membrane anchor 1) is a protein that is expressed in various tissues, including the brain, pancreas, and heart. It is characterized by the presence of a unique type of anchor, known as a proline-rich anchor, which is found in the cytoplasm of the cells.

The proline-rich anchor is a conserved region that is involved in various cellular processes, including cell adhesion, migration, and signaling. It is made up of a series of amino acids that are modified by substitution of proline residues. These substitutions can affect the localization and stability of the anchor, as well as its interactions with other proteins.

One of the unique features of PRIMA1 is its ability to interact with the protein PDZP (Porcine density-askew domain-containing), which is also known as PDZP2. These interactions play a role in the regulation of various cellular processes, including cell proliferation, differentiation, and survival.

In addition to its role in cell signaling, PRIMA1 is also a potential drug target. Its interaction with PDZP has been shown to be involved in the regulation of cell-cell interactions, which could make it an attractive target for small molecules that are designed to modulate these interactions.

Furthermore, recent studies have suggested that PRIMA1 may also be a biomarker for various diseases, including cancer. The high level of expression of PRIMA1 in various tissues and the presence of proline-rich anchors in other proteins suggest that it may be a useful biomarker for certain types of cancer.

The unique combination of features makes PRIMA1 a promising target for further research and potential therapeutic intervention. Further studies are needed to fully understand its role in cell signaling and its potential as a biomarker for disease.

Protein Name: Proline Rich Membrane Anchor 1

Functions: Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers (By similarity)

The "PRIMA1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PRIMA1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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