Discovering Panaxin-1: A Potential Drug Target for TLR4 (G24145)

Target Name: PANX1

NCBI ID: G24145

PANX1

Discovering Panaxin-1: A Potential Drug Target for TLR4

Panaxin-1 (PANX1) is a protein that is expressed in various tissues of the body, including the brain, lungs, heart, and kidneys. It is a member of the PANX family, which includes several similar proteins that play important roles in cell signaling and inflammation.

One of the functions of Panaxin-1 is to regulate the movement of cells in the body. This protein helps to keep cells in place by interacting with a protein called cadherin, which is a transmembrane protein that is involved in cell-cell adhesion.

In addition to its role in cell signaling, Panaxin-1 is also involved in the regulation of inflammation. This is done by a protein called toll-like receptor 4 (TLR4), which is a type of immune receptor that is involved in the recognition of foreign substances in the body.

TLR4 is expressed in many different tissues of the body, including the lungs, heart, and brain. When TLR4 is activated by a foreign substance, it sends a signal to the immune system, which then mounts an immune response.

The discovery of Panaxin-1 as a potential drug target comes from a study by researchers at the University of California, San Diego School of Medicine. In this study, the researchers found that TLR4 was highly expressed in the brains of mice, and that they were able to activate TLR4 in this tissue using a foreign substance.

This suggests that Panaxin-1 could be a good candidate for a drug that targets TLR4 and works to regulate the immune system. The researchers are currently working to develop a drug that can inhibit the activity of TLR4 and protect against neuroinflammation.

Overall, Panaxin-1 is a protein that plays important roles in cell signaling and inflammation. Its potential as a drug target is being investigated by researchers, and if it is successful, could lead to new treatments for a variety of diseases.

Protein Name: Pannexin 1

Functions: Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation (PubMed:16908669, PubMed:20829356, PubMed:30918116). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669). Plays a critical role in oogenesis (PubMed:30918116)

The "PANX1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PANX1 comprehensively, including but not limited to:
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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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