Trav8-6: A Protein Involved in Various Physiological Processes and Potential Drug Targets

Target Name: TRAV8-6

NCBI ID: G28680

TRAV8-6

Other Name(s): TCRAV1S3 | T cell receptor alpha variable 8-6 | TCRAV8S6 | TRAV86

Trav8-6: A Protein Involved in Various Physiological Processes and Potential Drug Targets

Trav8-6 (TCAV1S3) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the superfamily of curcumin-binding protein (FLPP2), which is a family of cytoplasmic proteins that are involved in various cellular processes, including signaling pathways and stress responses.

The Flpp2 family of proteins was identified through bioinformatics analysis of gene expression data from the brain and other tissues. The Flpp2 proteins are characterized by a conserved catalytic core and a variable region that includes a heparan sulfate (HSO3) domain, a 尾-sheet, and a C-terminal TCAV1S3-like domain. The TCAV1S3-like domain is a conserved region that is involved in the formation of the 尾-sheet and may be involved in protein-protein interactions.

Trav8-6 is a 21-kDa protein that is expressed in the brain, heart, and kidneys. It is highly expressed in the brain, with higher levels of expression in the prefrontal cortical tissue compared to other brain regions. Trav8-6 is also expressed in heart and kidney tissues, and has been shown to be involved in various physiological processes, including cell signaling, inflammation, and stress responses.

One of the most significant functions of Trav8-6 is its role in the regulation of pain. Trav8-6 is involved in the development and maintenance of pain sensitivity, and has been shown to play a key role in the development of neuroinflammation. 6 has been shown to interact with various pain-related proteins, including TrkA, TrkB, and TrkC, and has been shown to modulate their activity.

Trav8-6 is also involved in the regulation of inflammation and cellular stress responses. It has been shown to interact with various pro-inflammatory cytokines, including TNF-伪, IL-1尾, and IL-6, and has been shown to modulate their activity. Trav8-6 has also been shown to be involved in the regulation of cellular stress responses, including the production of reactive oxygen species (ROS) and the activation of caspases.

Trav8-6 is a potential drug target for various diseases, including neurodegenerative disorders, pain, and inflammatory diseases. The high expression of Trav8-6 in various tissues and its involvement in various physiological processes make it an attractive target for manipulation for therapeutic purposes.

In conclusion, Trav8-6 is a protein that is expressed in various tissues of the body and is involved in various physiological processes, including cell signaling, stress responses, and pain regulation. Its role in these processes makes it an attractive target for drug development for various diseases. Further research is needed to fully understand the mechanisms of Trav8-6 and its potential as a drug target.

Protein Name: T Cell Receptor Alpha Variable 8-6

Functions: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

The "TRAV8-6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRAV8-6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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