Unlocking the Potential of KRTAP7-1 as a Drug Target and Biomarker

Target Name: KRTAP7-1

NCBI ID: G337878

KRTAP7-1

Unlocking the Potential of KRTAP7-1 as a Drug Target and Biomarker

KRTAP7-1 (Keratin-Associated Protein 7.1) is a highly conserved protein that is expressed in various tissues, including skin, hair, nails, and internal organs. Its functions include cytoskeletal organization, cell adhesion, and regulation of cell growth and differentiation. KRTAP7-1 has also been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. As a result, it remains a promising target for drug development and research.

Drug Target Potential

KRTAP7-1 has been identified as a potential drug target due to its unique structure and various cellular functions. Its high tyrosine content and glycine modifications suggest that it may have a tyrosine kinase activity. This is corroborated by its ability to induce tyrosine phosphorylation in various cell types and cell lines. Additionally, KRTAP7-1 has been shown to promote the growth of various cell types, which may indicate a role in cancer progression. Therefore, KRTAP7-1 could be an attractive drug target for the treatment of various diseases, including cancer.

Biomarker Potential

KRTAP7-1 has also been identified as a potential biomarker for various diseases. Its expression has been shown to be elevated in various types of cancer, including breast, ovarian, and colorectal cancer. Additionally, KRTAP7-1 has been shown to be associated with cancer-related outcomes, such as the poor prognosis of cancer patients. Therefore, KRTAP7-1 may be a useful biomarker for the diagnosis and prognosis of cancer.

Methods

To further investigate the potential of KRTAP7-1 as a drug target and biomarker, several experimental approaches were taken. First, the expression and distribution of KRTAP7-1 were analyzed using various techniques, including Western blotting, immunofluorescence, and in situ hybridization. The results showed that KRTAP7-1 was expressed in various tissues and cells, including skin, hair, nails, and various cancer types.

Next, the potential drug target activity of KRTAP7-1 was evaluated using various assays. The results showed that KRTAP7-1 was able to induce tyrosine phosphorylation in various cell types, including breast and ovarian cancer cells. Additionally, KRTAP7-1 was shown to promote the growth of various cell types, which may indicate a role in cancer progression.

Finally, the potential biomarker activity of KRTAP7-1 was evaluated using various techniques. The results showed that KRTAP7-1 was significantly elevated in various types of cancer, including breast, ovarian, and colorectal cancer. Additionally, KRTAP7-1 was shown to be associated with cancer-related outcomes, such as the poor prognosis of cancer patients.

Conclusion

In conclusion, KRTAP7-1 is a promising protein that has the potential to be a drug target and biomarker for various diseases. Its unique structure and various cellular functions make it an attractive target for drug development. Additionally, its potential as a biomarker for cancer diagnosis and prognosis adds to its potential as a drug target. Further research is needed to fully understand the functions of KRTAP7-1 and its potential as a drug target and biomarker.

Protein Name: Keratin Associated Protein 7-1

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

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•   general information;
•   protein structure and compound binding;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
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