Discovering ZDHHC3: A Potential Drug Target Or Biomarker (G51304)

Target Name: ZDHHC3

NCBI ID: G51304

ZDHHC3

Discovering ZDHHC3: A Potential Drug Target Or Biomarker

Zinc Finger DHHC-Type Palmitoyl Transferase 3 (ZDHHC3) is a protein that is expressed in various tissues and cells throughout the body. It is a member of the DHHC family of enzymes, which are involved in the transfer of fatty acids from the palmitate or other fatty acid sources to the cell membrane. In this article, we will discuss ZDHHC3 as a potential drug target or biomarker.

The DHHC family of enzymes consists of four subfamilies, including DHHC1, DHHC2, DHHC3, and DHHC4. These enzymes share a conserved catalytic core and a similar mechanism of action, which involves the transfer of a fatty acid from a donor molecule to a acceptor molecule via a hydrophobic-binding protein (HBP) and a zinc finger domain. ZDHHC3 is a member of the DHHC3 subfamily, which is characterized by the presence of a zinc finger domain and the unique catalytic motif 尾-尾-伪-(2,4 -dihydroxybutane-1,2-diol)-尾-amyloidin.

The zinc finger domain is a structural motif that is composed of a central zinc atom that is surrounded by four amino acids. This domain is known for its ability to form a covalent complex with various small molecules, including drugs and toxins. In ZDHHC3, the zinc finger domain is responsible for the catalytic activity of the enzyme and is involved in the transfer of fatty acids from the palmitate to the cell membrane.

ZDHHC3 is involved in the synthesis of various fatty acids, including palmitoyl-CoA, which is a key precursor for the synthesis of triacylglycerols, which are involved in cellular signaling and energy storage. Palmitoyl-CoA is synthesized from palmitic acid, which is derived from the fatty acids that are present in various dietary sources. The synthesis of palmitoyl-CoA from palmitic acid is a critical step in the biosynthesis of various physiological compounds, including fatty acids, steroids, and vitamins.

In addition to its involvement in fatty acid synthesis, ZDHHC3 is also involved in the regulation of cellular signaling pathways. Many cellular signaling pathways involve the transfer of fatty acids from acceptor molecules to activator molecules, which can either activate or inhibit the signaling pathway. In ZDHHC3, the zinc finger domain is involved in the regulation of several cellular signaling pathways, including the TG/LPL signaling pathway, the fatty acid oxidation metabolism pathway, and the insulin signaling pathway.

The TG/LPL signaling pathway is involved in the regulation of triacylglycerol metabolism and is critical for the synthesis of fatty acids from dietary sources. The TG/LPL signaling pathway is also involved in the regulation of cellular signaling pathways, including the synthesis and storage of fatty acids. ZDHHC3 is known to play a role in the regulation of TG/LPL signaling pathway by affecting the activity of the enzymes that are involved in this pathway, including the transcription factor, the protein kinase, and the protein localized in the ER.

The fatty acid oxidation metabolic pathway is involved in the regulation of fatty acid oxidation and is critical for the production of fatty acids from fatty acid precursors. The fatty acid oxidation metabolic pathway is also involved in the regulation of cellular signaling pathways, including the production of fatty acids from fatty acid precursors. ZDHHC3 is known to play a role in the regulation of fatty acid oxidation metabolism pathway by affecting the activity of the enzymes that are involved in this pathway, including the

Protein Name: Zinc Finger DHHC-type Palmitoyltransferase 3

Functions: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:19001095, PubMed:21926431, PubMed:22240897, PubMed:23034182, PubMed:22314500). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (PubMed:19001095). Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (PubMed:22314500). Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (PubMed:22240897). In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation. Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses. Palmitoylates NCDN thereby regulating its association with endosome membranes. Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor. Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth. Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes. Also constitutively palmitoylates DLG4. May also palmitoylate SNAP25. Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (By similarity). Could also palmitoylate the D(2) dopamine receptor DRD2 (PubMed:26535572)

The "ZDHHC3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZDHHC3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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