PANK1: A Promising Drug Target / Biomarker (G53354)

Target Name: PANK1

NCBI ID: G53354

PANK1

PANK1: A Promising Drug Target / Biomarker

Pank1 is a protein that is expressed in various tissues throughout the body, including the brain, heart, kidneys, and liver. It is a key regulator of cell signaling pathways and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. While the exact function of pank1 is not yet fully understood, it is clear that it plays an important role in the regulation of cellular processes that are critical for human health and disease. As a drug target or biomarker, pank1 is of great interest to researchers because it provides a potential target for new therapies.

Pank1 and its Functions

Pank1 is a member of the TGF-β family of proteins, which are involved in the regulation of cell signaling pathways. TGF-β signaling pathways are involved in the development, maintenance, and regulation of tissues and organs, including the brain and spinal cord. Pank1 is involved in the regulation of TGF-β signaling by the negative regulator, TGF-β2.

One of the key functions of pank1 is its role in the regulation of neuronal differentiation. Pank1 is expressed in neural cells and has been shown to play a role in the regulation of neuronal stem cell proliferation and differentiation. In addition, pank1 has been shown to regulate the maturation of neurons, which is a critical step in the development of neural circuits.

In addition to its role in neuronal differentiation, pank1 is also involved in the regulation of inflammation. Pank1 has been shown to play a role in the regulation of immune cell function and has been implicated in the development of autoimmune disorders.

Pank1 and Cancer

One of the most promising applications of pank1 as a drug target is its potential to treat cancer. Pank1 has been shown to play a role in the regulation of cell signaling pathways, including the regulation of cell growth and the inhibition of cell proliferation. As a result, pank1 has been shown to be an attractive target for cancer therapies that aim to inhibit cell proliferation or promote cell death.

For example, studies have shown that inhibitors of pank1, such as inhibitors of the TGF-β signaling pathway, can inhibit the growth of cancer cells in cell culture and in animal models of cancer. In addition, pank1 has also been shown to play a role in the regulation of angiogenesis, which is the process by which new blood vessels are formed to supply oxygen and nutrients to cancer cells. As a result, inhibitors of pank1 may also have the potential to treat angiogenic diseases, such as cancer.

Pank1 and Neurodegenerative Diseases

Pank1 has also been implicated in the development and progression of neurodegenerative diseases. Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are characterized by the progressive loss of brain cells and the development of progressive neurological symptoms. These diseases are often treated with drugs that aim to slow down or stop the progression of neurodegeneration. In addition, pank1 has been shown to play a role in the regulation of neurodegenerative diseases by the regulation of cellular processes that are involved in the development and progression of these diseases.

For example, studies have shown that pank1 is involved in the regulation of the production of reactive oxygen species (ROS), which are highly reactive molecules that can cause damage to brain cells and contribute to the development and progression of neurodegenerative diseases. In addition, pank1 has also been shown to play a role in the regulation of the production of neurotransmitters, which are chemical messengers that are involved in the regulation of brain function.

Pank1 and Autoimmune Disorders

Pank1 has also been implicated in the development and progression of autoimmune disorders. Autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis, are characterized by the immune system attacking and damaging the body's own tissues. In addition, pank1 has been shown to play a role in the regulation of

Protein Name: Pantothenate Kinase 1

Functions: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis

The "PANK1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PANK1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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