Understanding The Potential Therapeutic Potential of Pank4 (G55229)

Target Name: PANK4

NCBI ID: G55229

PANK4

Understanding The Potential Therapeutic Potential of Pank4

Pank4, also known as 4'-phosphopantetheine phosphatase, is a protein that is expressed in various tissues throughout the body. It is a critical enzyme that is involved in the metabolism of RNA, specifically microRNA (miRNA). Pank4 is highly conserved across various species, and it has been identified as a potential drug target and biomarker.

Pank4 is a single-pass enzyme that catalyzes the chemical reaction known as poly(A) polymerase (PA polymerase), which is essential for the production of functional RNA molecules. PA polymerase is a critical enzyme that is involved in the production of miRNA, which are small non-coding RNAs that play a crucial role in post-transcriptional gene regulation.

MicroRNA molecules are designed to target specific mRNAs for degradation, and they are involved in a wide range of cellular processes, including cell growth, apoptosis, and transcriptional regulation. Pank4 is a key enzyme that is involved in the production of microRNA molecules, which suggests that it may be a potential drug target or biomarker.

One of the key advantages of Pank4 is its expression profile. Pank4 is highly expressed in various tissues, including brain, heart, and testes, and its expression level is regulated by various signaling pathways. For example, Pank4 is regulated by the negative signaling pathway, which includes the TGF-β pathway. This pathway is involved in cell growth, differentiation, and survival, and it is potential target for drugs that are designed to inhibit TGF-β signaling.

Another potential mechanism by which Pank4 may be targeted by drugs is its role in cancer development. Pank4 is involved in the regulation of cell cycle progression, and its expression is associated with the growth and survival of various cancer cells. For example, studies have shown that Pank4 is highly expressed in human cancer cells, and that inhibition of Pank4 has been shown to inhibit the growth and survival of these cells. This suggests that Pank4 may be a potential drug target or biomarker for cancer therapies.

In addition to its potential as a drug target or biomarker, Pank4 is also a potential biomarker for various diseases. For example, Pank4 is highly expressed in individuals with Down syndrome, and its expression level is associated with the cognitive and behavioral deficits that are observed in this condition. Additionally, Pank4 is highly expressed in individuals with Alzheimer's disease, and its expression level is associated with the cognitive decline and neurodegeneration that are observed in this condition.

In conclusion, Pank4 is a highly conserved protein that is involved in the metabolism of RNA. It is a critical enzyme that is involved in the production of microRNA molecules, and it is highly expressed in various tissues throughout the body. The potential targets for Pank4 include the TGF-β pathway, cancer cells, and individuals with Down syndrome and Alzheimer's disease. Further research is needed to fully understand the role of Pank4 in cellular and biological processes, and to develop effective therapies that target this protein.

Protein Name: Pantothenate Kinase 4 (inactive)

Functions: Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068). Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068). Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068). May play a role in the physiological regulation of CoA intracellular levels (Probable)

The "PANK4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PANK4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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