Target Name: RNF125
NCBI ID: G54941
Review Report on RNF125 Target / Biomarker Content of Review Report on RNF125 Target / Biomarker
RNF125
Other Name(s): TRAC1 | Ring finger protein 125 | T-cell RING activation protein 1 | TRAC-1 | MGC21737 | FLJ20456 | E3 ubiquitin-protein ligase RNF125 | ring finger protein 125, E3 ubiquitin protein ligase | RN125_HUMAN | T-cell ring protein identified in activation screen | ring finger protein 125 | TNORS | RING finger protein 125

TRAC1: A Key Regulator of DNA Replication, Cell Growth, Apoptosis and Immune Response

RNA-Nucleic Acid-Protein Complex (RNP) proteins play a crucial role in various cellular processes, including DNA replication, gene expression, and intracellular signaling. One of the key subfamilies of RNP proteins is the TRAC1 (T-cell nuclear import factor 1) family, which is composed of six protein subunits that form a complex with DNA in the nucleus. TRAC1 is a key regulator of DNA replication and has been implicated in numerous cellular processes, including the regulation of cell growth, apoptosis, and immune response.

The TRAC1 protein is a 23-kDa nucleic acid-protein complex that consists of six subunits: TRAC1, TRAC2, TRAC3, TRAC4, TRAC5, and TRAC6. These subunits form a stable complex with DNA in the nucleus, where they play important roles in various cellular processes, including the regulation of gene expression, DNA replication, and cell signaling pathways.

One of the key functions of TRAC1 is its role in regulating DNA replication. TRAC1 has been shown to play a critical role in the regulation of DNA replication in various cell types, including T cells, where it is required for the efficient translation of DNA template into RNA and the establishment of a stable double-stranded DNA replication complex. In addition to its role in DNA replication, TRAC1 has also been shown to play a critical role in the regulation of gene expression and cellular signaling pathways.

TRAC1 has been shown to play a critical role in the regulation of cell growth and apoptosis. In addition to its role in regulating DNA replication, TRAC1 has also been shown to play a critical role in the regulation of cell growth and apoptosis. For example, TRAC1 has been shown to play a critical role in the regulation of cell cycle progression, and has been shown to interact with various cellular signaling pathways, including the T-cell signaling pathway.

TRAC1 has also been shown to play a critical role in the regulation of immune response. In addition to its role in regulating cell growth and apoptosis, TRAC1 has also been shown to play a critical role in the regulation of the immune response. For example, TRAC1 has been shown to play a critical role in the regulation of T-cell receptor (TCR) function, and has been shown to interact with various cellular signaling pathways, including the DNA-protein complex at the nuclear-cytoplasmic interface.

Despite its important role in various cellular processes, TRAC1 is not well understood, and much of its function remains unexplored. In addition to its role in regulating DNA replication, TRAC1 has also been shown to play a critical role in the regulation of cell growth, apoptosis, and immune response, and as such, it is a potential drug target and biomarker.

TRAC1 has been shown to interact with various cellular signaling pathways, including the T-cell signaling pathway. This suggests that TRAC1 may play a critical role in the regulation of T-cell function and that it may be a useful target for the development of new therapies for T-cell-related diseases. In addition, TRAC1 has also been shown to play a critical role in the regulation of DNA replication, which suggests that it may be a useful target for the development of new therapies for DNA replication-related diseases.

In conclusion, TRAC1 is a key regulator of various cellular processes, including DNA replication, cell growth, apoptosis, and immune response. Its role in these processes makes it a potential drug target and biomarker, and its function remains an area of ongoing research. Further studies are needed to fully understand the functions of TRAC1 and its potential as a drug target.

Protein Name: Ring Finger Protein 125

Functions: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation (PubMed:17460044, PubMed:26471729). Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934). Acts as a positive regulator of T-cell activation (PubMed:15843525)

The "RNF125 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNF125 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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