ABR: A Versatile Protein with Potential as A Drug Target Or Biomarker

Target Name: ABR

NCBI ID: G29

Content of Review Report on ABR Target / Biomarker

ABR

ABR: A Versatile Protein with Potential as A Drug Target Or Biomarker

ABR (Alkylator-Binding Receptor) is a protein that is expressed in various tissues throughout the body, including the brain, spleen, and gastrointestinal tract. It is a member of the superfamily of transmembrane protein receptors, which are characterized by the presence of a transmembrane segment and a cytoplasmic tail. ABR plays an important role in the regulation of cellular processes, including cell signaling, cell adhesion, and neurotransmitter release.

The ABR protein is composed of four structural domains: an extracellular domain, a transmembrane domain, an intracellular domain, and a N-terminal domain. The extracellular domain is responsible for the protein's ability to interact with various signaling molecules, including small molecules, peptides , and proteins. The transmembrane domain is responsible for the protein's ability to span the cell membrane and for its role in cell signaling. The intracellular domain is responsible for the protein's ability to interact with various intracellular signaling pathways, including the tight-packed protein- protein interaction (PPI) network and the signal transduction pathway. The N-terminal domain is responsible for the protein's ability to interact with DNA and for its role in gene regulation.

ABR is a versatile protein that can be modified to serve as a drug target or biomarker. One of the most promising applications of ABR is as a drug target. The ability of ABR to interact with small molecules and other signaling molecules makes it an attractive target for drug development. Several studies have shown that ABR is involved in a wide range of cellular processes, including the regulation of neurotransmitter release, cell signaling, and cell adhesion. This makes it an attractive target for the development of new drugs that can modulate these processes.

In addition to its potential as a drug target, ABR is also a useful biomarker for a variety of diseases. The ability of ABR to be expressed in various tissues makes it an attractive target for the development of tissue-specific diagnostic tools. Several studies have shown that ABR is involved in the regulation of a wide range of cellular processes, including neurotransmitter release, cell signaling, and cell adhesion. This makes it an attractive target for the development of biomarkers that can be used to diagnose and monitor a variety of diseases , including neurodegenerative disorders, psychiatric disorders, and inflammatory diseases.

Overall, ABR is a protein that is rich in function and has a wide range of potential applications as a drug target or biomarker. Its ability to interact with small molecules and other signaling molecules makes it an attractive target for drug development, and its ability to be expressed in various tissues makes it an attractive target for the development of tissue-specific diagnostic tools. Further research is needed to fully understand the full potential of ABR as a drug target and biomarker.

Protein Name: ABR Activator Of RhoGEF And GTPase

Functions: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:7479768, PubMed:17116687). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity)

The "ABR Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ABR comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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