ACAD11: A Potential Drug Target (G84129)

Target Name: ACAD11

NCBI ID: G84129

ACAD11

ACAD11: A Potential Drug Target

ACAD11 (MGC150619) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the adapter protein family, which plays a critical role in the regulation of cell-signaling pathways. Studies have identified ACAD11 as a potential drug target (or biomarker) due to its unique structure, expression pattern and role in various physiological and pathological processes.

Structure and Expression

ACAD11 is a 21-kDa protein that consists of a 21-kDa extracellular domain and a 96-kDa transmembrane domain. The extracellular domain is characterized by a N-terminal alpha-helix structure, which is thought to play a role in the protein's stability and function. The transmembrane domain is made up of a variable number of transmembranespanning segments, each of which is characterized by a unique arrangement of amino acids.

ACAD11 is expressed in a variety of tissues and organs, including the brain, heart, and kidneys. In the brain, ACAD11 is expressed in the postsynaptic density of dendrites, the cell body, and the axon. In the heart, ACAD11 is expressed in the myocardium, the epicardium, and the pericardium. In the kidneys, ACAD11 is expressed in the podocytes, the interstitial cells, and the mesangium.

Function

ACAD11 is involved in the regulation of cell-signaling pathways that are critical for various physiological processes, including cell growth, differentiation, and survival. One of the key functions of ACAD11 is its role in the regulation of the sprouting angiogenesis that occurs during the development and maintenance of tissues.

In addition to its role in sprouting angiogenesis, ACAD11 is also involved in the regulation of cell-cell adhesion, as well as the regulation of ion and water transport. This is evident from the fact that ACAD11 is a component of several membrane-bound proteins that are involved in these processes.

Drug Targeting

ACAD11 is a potential drug target due to its unique structure and expression pattern, as well as its involvement in various physiological processes. Several studies have identified ACAD11 as a potential drug target, and further research is being conducted to determine its effectiveness.

One of the potential benefits of targeting ACAD11 is its ability to modulate the activity of several intracellular signaling pathways, including the PI3K/Akt signaling pathway, the TGF-β signaling pathway, and the Wnt signaling pathway. This suggests that targeting ACAD11 may be an Effective way to treat a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

Another potential benefit of targeting ACAD11 is its ability to modulate the expression of genes involved in cell-cycle progression, apoptosis, and inflammation. This suggests that targeting ACAD11 may be an effective way to treat diseases that are characterized by the disruption of normal cell- cycle regulation, such as cancer.

Conclusion

ACAD11 is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the adapter protein family and is involved in the regulation of cell-signaling pathways that are critical for various physiological processes . Studies have identified ACAD11 as a potential drug target due to its unique structure, expression pattern, and involvement in intracellular signaling pathways. Further research is being conducted to determine its effectiveness as a drug target.

Protein Name: Acyl-CoA Dehydrogenase Family Member 11

Functions: Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA (PubMed:21237683). Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain (Probable)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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