ABRAXAS1: A Potential Drug Target for Various Diseases (G84142)

Target Name: ABRAXAS1

NCBI ID: G84142

ABRAXAS1

ABRAXAS1: A Potential Drug Target for Various Diseases

ABRAXAS1 (FAM175A) is a protein that is expressed in various tissues of the body, including the brain, heart, kidneys, and intestines. It is a member of the FAM (fucosin) family of proteins, which are known for their role in cell-cell adhesion and signaling.

Recent studies have identified ABRAXAS1 as a potential drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This is because ABRAXAS1 has been shown to play a role in the development and progression of these conditions.

One of the reasons for the interest in ABRAXAS1 is its ability to interact with several different signaling pathways. For example, studies have shown that ABRAXAS1 can interact with the TGF-β pathway, which is involved in cell growth, differentiation, and survival. This interaction suggests that ABRAXAS1 may be a useful target for drugs that are designed to inhibit TGF-β signaling.

Another study found that ABRAXAS1 was involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. This suggests that ABRAXAS1 may be a useful target for drugs that are designed to prevent or treat these conditions.

In addition to its potential role in disease, ABRAXAS1 has also been shown to have potential therapeutic applications. For example, studies have shown that ABRAXAS1 can be used to deliver small molecules to specific tissues in the body, such as cancer cells. This suggests that ABRAXAS1 may be a useful target for drugs that are designed to deliver therapeutic agents to cancer cells.

Overall, the potential drug targets for ABRAXAS1 are vast and varied. As more research is done on this protein, it is likely that we will uncover even more ways in which ABRAXAS1 can be leveraged for therapeutic purposes.

Protein Name: Abraxas 1, BRCA1 A Complex Subunit

Functions: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX

The "ABRAXAS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ABRAXAS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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