ABRAXAS2: A Potential Drug Target and Biomarker (G23172)

Target Name: ABRAXAS2

NCBI ID: G23172

ABRAXAS2

ABRAXAS2: A Potential Drug Target and Biomarker

ABraXAS2 (Abraxas brother protein 1) is a protein that is expressed in various tissues of the human body, including the brain, heart, and kidneys. It is a member of the superfamily of transmembrane proteins, which are involved in various physiological processes in the body. One of the unique features of ABraXAS2 is its ability to interact with various signaling molecules, including Wnt, Notch, and TGF-β. This protein has been shown to play a role in various physiological processes, including cell survival, migration, and invasion.

Drug Target Potential

The potential drug targets for ABraXAS2 are numerous and varied. One of the primary targets of ABraXAS2 is its role in the development and progression of cancer. Several studies have shown that ABraXAS2 is involved in the regulation of cell proliferation and has been implicated in the development of various types of cancer, including neurobladder cancer, ovarian cancer, and breast cancer.

Another potential drug target for ABraXAS2 is its role in the regulation of cellular migration and invasion. Several studies have shown that ABraXAS2 is involved in the regulation of cell migration and has been implicated in the development of various types of cancer, including melanoma, colon cancer, and lung cancer.

Biomarker Potential

ABraXAS2 has also been shown to be a potential biomarker for various types of cancer. Several studies have shown that ABraXAS2 is expressed in various types of cancer and has been used as a potential biomarker for these conditions. For example, one study showed that ABraXAS2 was expressed in various types of cancer, including breast cancer, and was used as a potential biomarker for these conditions.

Another study showed that ABraXAS2 was expressed in various types of cancer, including lung cancer, and was used as a potential biomarker for these conditions.

Conclusion

In conclusion, ABraXAS2 is a protein that has been shown to play a role in various physiological processes in the human body. Its potential drug targets are numerous and varied, including the regulation of cancer development and the regulation of cellular migration and invasion. Additionally, ABraXAS2 has also been shown to be a potential biomarker for various types of cancer. Further research is needed to fully understand the role of ABraXAS2 in these processes and to develop effective therapies.

Protein Name: Abraxas 2, BRISC Complex Subunit

Functions: Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148)

The "ABRAXAS2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ABRAXAS2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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