ABL2: Key Regulator of Cell Growth and Survival (G27)

Target Name: ABL2

NCBI ID: G27

ABL2

ABL2: Key Regulator of Cell Growth and Survival

ABL2 (Tyrosine-protein kinase ABL2 (isoform b)) is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. It is a key regulator of cell growth and proliferation, and is involved in the development and maintenance of tissues.

ABL2 is a tyrosine-protein kinase, which means that it is a protein that is involved in the signaling process of the tyrosine pathway. The tyrosine pathway is a signaling pathway that is involved in the regulation of cell growth, differentiation, and survival.

ABL2 is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. It is a key regulator of cell growth and proliferation, and is involved in the development and maintenance of tissues.

One of the functions of ABL2 is to regulate the growth and survival of cells. It does this by signaling the tyrosine pathway, which is a signaling pathway that is involved in the regulation of cell growth, differentiation, and survival.

ABL2 is a protein that is involved in the regulation of cell growth and survival. It does this by signaling the tyrosine pathway, which is a signaling pathway that is involved in the regulation of cell growth, differentiation, and survival.

Another function of ABL2 is to regulate the movement of cells. It does this by signaling the MAPK/ERK signaling pathway, which is a signaling pathway that is involved in the regulation of cell growth, differentiation, and survival.

ABL2 is a protein that is involved in the regulation of cell growth and survival. It does this by signaling the tyrosine pathway and the MAPK/ERK signaling pathway, which are both involved in the regulation of cell growth, differentiation, and survival.

In addition to its role in cell growth and survival, ABL2 is also involved in the regulation of cell-cell interactions. It does this by signaling the JAK/STAT signaling pathway, which is a signaling pathway that is involved in the regulation of cell-cell interactions.

ABL2 is a protein that is involved in the regulation of cell growth and survival, as well as cell-cell interactions. It does this by signaling the tyrosine pathway, the MAPK/ERK signaling pathway, and the JAK/STAT signaling pathway.

Despite the fact that ABL2 is involved in a number of important functions, it is not yet widely understood. This is because it is a relatively small protein, and there is not much research available on its function.

One of the challenges in studying ABL2 is its relatively small size. This makes it difficult to study its function in isolation, and to understand how it interacts with other proteins.

Another challenge in studying ABL2 is its involvement in a number of different signaling pathways. This makes it difficult to understand its function in the context of these signaling pathways, and to determine how it contributes to the regulation of cell growth and survival.

Despite these challenges, there is growing interest in studying ABL2, and the results of some studies suggest that it may be a potential drug target or biomarker. For example, some studies have suggested that ABL2 may be involved in the regulation of cancer cell growth and survival.

In addition, there is also some evidence to suggest that ABL2 may be involved in the regulation of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. This is because ABL2 has been shown to be involved in the regulation of the neurotransmitter serotonin, which is involved in the regulation of mood, appetite, and other physiological processes.

Overall, the study of ABL2 is an important step in the understanding of its function and potential applications. Further research is needed to fully understand its role in the regulation of cell growth and survival, as well as its potential as a drug target or biomarker.

Protein Name: ABL Proto-oncogene 2, Non-receptor Tyrosine Kinase

Functions: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity)

The "ABL2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ABL2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets