MARCHF7: A Potential Drug Target for Various Diseases (G64844)

Target Name: MARCHF7

NCBI ID: G64844

MARCHF7

MARCHF7: A Potential Drug Target for Various Diseases

MARCHF7 (AXO) is a protein that is expressed in various tissues of the body, including the brain, heart, and liver. It is a member of the MARCHF7 family of proteins, which are characterized by the presence of a specific domain called the N -terminal alpha-spiral.

One of the unique features of MARCHF7 is its ability to form aggregates in culture. This aggregation is highly dynamic and can be reversed by various treatments, such as the addition of small molecules or the addition of antibodies that target specific regions of the protein.

The MARCHF7 protein is also known for its role in the regulation of cell adhesion. It is a key regulator of tight junctions, which are a type of cell-cell adhesion that helps to maintain tissue structure and function.

In addition to its role in cell adhesion, MARCHF7 has also been shown to play a role in the regulation of cell survival. Studies have shown that MARCHF7 can inhibit the progression of spindle-induced apoptosis, which is the process by which cells die as a result of the formation of the progressing spindle.

The MARCHF7 protein is also a potential drug target (or biomarker) because of its ability to form aggregates in culture and its role in the regulation of cell adhesion and survival. This makes it an attractive target for the development of new treatments for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

In conclusion, MARCHF7 is a protein that is expressed in various tissues of the body and is characterized by its ability to form aggregates in culture. It is also known for its role in the regulation of cell adhesion and survival. As a result, it is a potential drug target (or biomarker) and could be used to develop new treatments for various diseases.

Protein Name: Membrane Associated Ring-CH-type Finger 7

Functions: E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356)

The "MARCHF7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MARCHF7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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