NETO2: A Brain-Specific Transmembrane Protein Containing 2 CUB and 1 LDL-Receptor Class A Domains

Target Name: NETO2

NCBI ID: G81831

NETO2

NETO2: A Brain-Specific Transmembrane Protein Containing 2 CUB and 1 LDL-Receptor Class A Domains

Networks of transmembrane proteins play a crucial role in various biological processes, including signaling and intracellular trafficking. NETO2, a protein containing two CUB and one LDL-receptor Class A domains, is considered an important molecule in the nervous system. In this article, we will explore the role of NETO2 in neuronal function and disease, as well as its importance as a potential drug target.

NETO2 is a transmembrane protein containing two CUBs, which are hydrophobic amino acid residues near the C-terminus. The second CUB of NETO2 is located at amino acid residue 21, which interacts with other proteins, including DLR1. The first CUB of NETO2 is located at amino acid residue No. 12, which binds to lipids and increases the stability of NETO2.

NETO2 also contains an LDL-receptor Class A domain, which is an important functional domain located at the N-terminus of the protein. LDL-receptor is a transcription factor that regulates intracellular signaling in neurons. By interacting with the CUB and LDL-receptor Class A domains of NETO2, NETO2 plays an important biological role in the nervous system.

The role of NETO2 in the nervous system includes regulating the growth and apoptosis of neurons, participating in the formation and maintenance of synapses between neurons, and regulating neuronal metabolism. In the growth and apoptosis of neurons, the role of NETO2 is crucial. In neuronal apoptosis, the activity of NETO2 increases, leading to neuronal death, thus clearing damaged neurons. During the growth of neurons, the activity of NETO2 is reduced, promoting the growth and branching of neurons.

NETO2 is also involved in the formation and maintenance of synapses between neurons. In interneuron synapses, NETO2's CUB binds to receptors on neuronal membranes, increasing signal transmission between neurons. In addition, the LDL-receptor Class A domains of NETO2 bind to lipids on the neuronal membrane to stabilize the synaptic structure, thus enhancing the ability of synapses to transmit signals.

NETO2 also regulates neuronal metabolism. In neuronal metabolism, the activity of NETO2 increases, increasing the potential changes on the neuronal membrane, thereby increasing the electrochemical gradient within the neuron. This electrochemical gradient drives the flow of ions within neurons and regulates the metabolic activity of neurons.

As an important molecule, NETO2 plays an important role in the nervous system. However, NETO2 also serves as a potential drug target for the treatment of various neurological diseases. For example, NETO2 activity can treat neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease by regulating neuronal apoptosis. The activity of NETO2 can also treat neurometabolic diseases, such as diabetes, by regulating neuronal metabolism.

NETO2 is also closely related to neuronal growth and apoptosis. Studies have shown that the activity of NETO2 changes during the aging process of neurons. With age, the activity of NETO2 gradually increases, leading to neuronal aging and apoptosis. Therefore, NETO2 can be used as a target for treating neuronal aging.

NETO2 is a molecule that plays an important role in the nervous system. Its activity regulates neuronal growth and apoptosis, and participates in synapses between neurons.

Protein Name: Neuropilin And Tolloid Like 2

Functions: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity)

The "NETO2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NETO2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets