Target Name: NUF2
NCBI ID: G83540
Review Report on NUF2 Target / Biomarker Content of Review Report on NUF2 Target / Biomarker
NUF2
Other Name(s): hNuf2 | CT106 | NUF2_HUMAN | hsNuf2 | cell division cycle-associated protein 1 | hNuf2R | Kinetochore protein Nuf2 | Cell division cycle-associated protein 1 | CDCA1 | NUF2 component of NDC80 kinetochore complex | NUF2 component of NDC80 kinetochore complex, transcript variant 1 | cell division cycle associated 1 | NUF2 variant 1 | NUF2 component of NDC80 kinetochore complex, transcript variant 2 | NUF2 variant 2 | NUF2, NDC80 kinetochore complex component, homolog | NUF2R | cancer/testis antigen 106 | NDC80 kinetochore complex component NUF2

NUF2: A Potential Drug Target and Biomarker

The neurotransmitter N-acetylcholine (NACh) is a crucial neurotransmitter that plays a vital role in the communication of the central nervous system (CNS) to the peripheral nervous system (PNS). NACh is synthesized by the amino acid N-acetylcholine (NACh) gene and its expression is regulated by various factors, including DNA methylation, histone modifications, and post-transcriptional modifications. One of the critical post-transcriptional modifications is phosphorylation, which is the covalent addition of a phosphate group to a specific amino acid residue. NUF2, a non-coding RNA molecule, has been shown to play a critical role in the regulation of NACh phosphorylation and its associated proteins.

NUF2 is a small non-coding RNA molecule that contains 199 amino acid residues and is located in the nucleus of the cell. It is characterized by a specific N-end, a unique feature that is found in a small number of non-coding RNAs. The function of NUF2 is not well understood, but its role in the regulation of NACh phosphorylation is well established.

NUF2 has been shown to play a critical role in the regulation of NACh phosphorylation at its N-end. NUF2 contains a conserved region, known as the NUF2-ASP-NACh interaction, which is involved in the regulation of NACh phosphorylation. This interaction is formed by the NUF2 protein and the N-acetylcholine receptor, which is a critical protein for the transmission of NACh signals from the CNS to the PNS.

NUF2 has been shown to play a critical role in the regulation of NACh phosphorylation at its N-end by interacting with the N-acetylcholine receptor. NUF2 has been shown to form a complex with the N-acetylcholine receptor and the protein kinase A1 (PKA), which is responsible for the phosphorylation of NACh at its N-end. This interaction between NUF2 and PKA has been shown to play a critical role in the regulation of NACh phosphorylation and its associated proteins.

In addition to its role in the regulation of NACh phosphorylation, NUF2 has also been shown to play a critical role in the regulation of gene expression. NUF2 has been shown to interact with the protein Skratch, which is a negative regulator of gene expression. This interaction between NUF2 and Skratch has been shown to play a critical role in the regulation of NACh phosphorylation and its associated proteins.

NUF2 has also been shown to play a critical role in the regulation of cellular processes, including cell growth, apoptosis, and inflammation. NUF2 has been shown to interact with the protein NF-kappa-B, which is a critical transcription factor that regulates cellular processes. This interaction between NUF2 and NF-kappa-B has been shown to play a critical role in the regulation of NACh phosphorylation and its associated proteins.

Given the critical role of NUF2 in the regulation of NACh phosphorylation, it is a potential drug target and biomarker for various neurological and psychiatric disorders. The regulation of NACh phosphorylation by NUF2 is a complex process that involves multiple interactions with various proteins, including the N-acetylcholine receptor, PKA, Skratch, and NF-kappa-B. Further studies are needed to fully understand the function of NUF2 in the regulation of NACh phosphorylation and its associated proteins.

In conclusion, NUF2 is a small non-coding RNA molecule that plays a critical role in the regulation of NACh phosphorylation and its associated proteins. NUF2 has been shown to interact with the N-acetylcholine receptor, PKA, Skratch, and NF-kappa-B, which are critical proteins for the transmission of NACh signals from the CNS to the PNS. Given its critical role in the regulation of NACh phosphorylation, NUF2 is a potential drug target and biomarker for various neurological and psychiatric disorders. Further studies are needed to fully understand the function of NUF2 in the regulation of NACh phosphorylation and its associated proteins.

Protein Name: NUF2 Component Of NDC80 Kinetochore Complex

Functions: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020)

The "NUF2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NUF2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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NUFIP1 | NUFIP2 | NUGGC | NUMA1 | NUMB | NUMBL | NUP107 | Nup107-160 complex | NUP133 | NUP153 | NUP155 | NUP160 | NUP188 | NUP205 | NUP210 | NUP210L | NUP210P1 | NUP210P2 | NUP214 | NUP35 | NUP37 | NUP42 | NUP43 | NUP50 | NUP50-DT | NUP54 | NUP58 | NUP62 | NUP62CL | NUP85 | NUP88 | NUP93 | NUP98 | NUPR1 | NUPR2 | NUS1 | NUS1P1 | NUS1P3 | NUSAP1 | NUTF2 | NUTF2P4 | NUTM1 | NUTM2A | NUTM2A-AS1 | NUTM2B | NUTM2B-AS1 | NUTM2D | NUTM2E | NUTM2F | NUTM2G | NVL | NWD1 | NWD2 | NXF1 | NXF2 | NXF3 | NXF4 | NXF5 | NXN | NXNL1 | NXNL2 | NXPE1 | NXPE2 | NXPE3 | NXPE4 | NXPH1 | NXPH2 | NXPH3 | NXPH4 | NXT1 | NXT2 | NXTAR | NYAP1 | NYAP2 | NYNRIN | NYX | OACYLP | OAF | OARD1 | OAS1 | OAS2 | OAS3 | OASL | OAT | OATP1 | OAZ1 | OAZ2 | OAZ3 | OBI1 | OBI1-AS1 | OBP2A | OBP2B | OBSCN | OBSCN-AS1 | OBSL1 | OC90 | OCA2 | OCEL1 | OCIAD1 | OCIAD2