Immunoproteasome: A Protein Complex Regulating Immune Response and Inflammation

Target Name: Immunoproteasome

NCBI ID: P16179

Immunoproteasome

Other Name(s): None

Immunoproteasome: A Protein Complex Regulating Immune Response and Inflammation

The immunoproteasome is a highly conserved protein complex that plays a critical role in the regulation of immune responses and inflammation. It is a complex of proteins that work together to process and present antigens to the immune system, thereby activating an immune response.

The immunoproteasome is composed of several subunits that include the 尾-secretase (BSS) subunit, the 纬-secretase (纬S) subunit, and the 未-secretase (未S) subunit. The BSS subunit is responsible for cleavage of the immunoglobulin (Ig) light chains at its constant region region, creating two light chains. The 纬S subunit is responsible for processing the light chains and creating a single heavy chain. The 未S subunit is responsible for processing the heavy chain and creating a single variable chain and a single fragment.

The immunoproteasome plays a critical role in the regulation of the immune response by presenting antigens to T-cells. When an antigen is processed by the immunoproteasome, it is presented to the major histocompatibility complex (MHC) class I molecules on the surface of the antigen -presenting cell (APC). The MHC molecules are responsible for presenting antigens to T-cells, which then differentiate into effector T-cells that recognize and respond to the antigens.

The immunoproteasome is also involved in the regulation of inflammation. When an inflammatory response is initiated, the immunoproteasome is activated and works to clear out damaged or dysfunctional cells, thereby limiting the inflammatory response. Additionally, the immunoproteasome is involved in the regulation of the cytokine network, which is responsible for the production and regulation of cytokines that play a critical role in the immune response.

Due to its critical role in the immune response and inflammation, the immunoproteasome has become an attractive drug target for researchers. Many studies have identified potential small molecules that can inhibit the immunoproteasome, thereby modulating the immune response. These small molecules include inhibitors of the BSS subunit, the 纬S subunit, and the 未S subunit.

One of the most promising small molecules for targeting the immunoproteasome is a compound called Y-27235, which is a glycosylation small molecule self-assembly inhibitor. Y-27235 was shown to inhibit the immunoproteasome by preventing the formation of the 纬- secretase (纬S) subunit. In addition, Y-27235 was shown to induce apoptosis (programmed cell death) in CD4+ T-cells, which is a hallmark of the immunoproteasome being activated and causing inflammation.

Another promising small molecule for targeting the immunoproteasome is a compound called IM-1421, which is a 纬-secretase inhibitor. IM-1421 was shown to inhibit the immunoproteasome by preventing the formation of the 纬S subunit. In addition, IM-1421 was shown to decrease the production of pro-inflammatory cytokines in CD4+ T-cells, thereby limiting the inflammatory response.

In conclusion, the immunoproteasome is a critical protein complex that plays a critical role in the regulation of the immune response and inflammation. The immunoproteasome is involved in the processing and presentation of antigens to the immune system, as well as the regulation of the cytokine network . As a result, the immunoproteasome has become an attractive drug target for researchers, with many studies showing potential small molecules that can inhibit or modulate the immunoproteasome. Further research is needed to

Protein Name: Immunoproteasome

The "Immunoproteasome Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about Immunoproteasome comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets