PLIN3: A Potential Drug Target for Pain Disorders (G10226)

Target Name: PLIN3

NCBI ID: G10226

PLIN3

PLIN3: A Potential Drug Target for Pain Disorders

PLIN3, also known as perilipin-3, is a protein that is expressed in various tissues throughout the body. It is a member of the PIP family, which includes proteins that are involved in the regulation of ion channels and signaling pathways. PLIN3 has been shown to play a role in the regulation of pain signaling, and is Therefore, it is a potential drug target or biomarker for the treatment of pain disorders.

The PIP family of proteins is characterized by the presence of a unique C-terminus domain, which is composed of a series of conserved amino acids that are involved in the formation of a hydrogen bond with other proteins. This domain is also known as the \"perilipin\" domain, and is thought to play a key role in the protein's stability and interactions with other molecules.

PLIN3 is a 12-kDa protein that is expressed in various tissues, including the brain, liver, and muscle. It is primarily localized to the endoplasmic reticulum, where it is involved in the regulation of the levels of various proteins in the cell. PLIN3 has been shown to play a role in the regulation of pain signaling by the production of pro-inflammatory cytokines, such as TNF-alpha and IL-1.

PLIN3 is also involved in the regulation of neurotransmitter signaling pathways, which are critical for the transmission of signals between neurons. It has been shown to interact with the neurotransmitter GABA, which is involved in the regulation of anxiety and other neurological disorders.

In addition to its role in pain and neurotransmitter signaling, PLIN3 is also involved in the regulation of cell survival and proliferation. It has been shown to play a role in the regulation of cell apoptosis, which is the process by which cells die as a result of environmental or genetic stress.

PLIN3 is also a potential biomarker for the diagnosis and monitoring of various diseases, including cancer. It has been shown to be expressed in the brains of patients with various types of cancer, and has been used as a target for small molecule inhibitors that can inhibit its activity.

In conclusion, PLIN3 is a protein that is involved in the regulation of various physiological processes in the body. Its role in pain and neurotransmitter signaling, as well as its involvement in cell survival and proliferation, make it a potential drug target or biomarker for the treatment of pain disorders and other diseases. Further research is needed to fully understand the role of PLIN3 in these processes and to develop effective treatments.

Protein Name: Perilipin 3

Functions: Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177)

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•   general information;
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•   expression level;
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