CACNG3: A Potential Drug Target and Biomarker for Gamma-3 Subunit of Transient Adrenaline Receptor

Target Name: CACNG3

NCBI ID: G10368

CACNG3

Other Name(s): TARP gamma-3 | transmembrane AMPAR regulatory protein gamma-3 | Voltage-dependent calcium channel gamma-3 subunit | calcium voltage-gated channel auxiliary subunit gamma 3 | Neuronal voltage-gated calcium channel gamma-3 subunit | Transmembrane AMPAR regulatory protein gamma-3 | Voltage-gated calcium channel gamma subunit | calcium channel, voltage-dependent, gamma subunit 3 | Calcium voltage-gated channel auxiliary subunit gamma 3 | CCG3_HUMAN | voltage-gated calcium channel gamma subunit | neuronal voltage-gated calcium channel gamma-3 subunit

CACNG3: A Potential Drug Target and Biomarker for Gamma-3 Subunit of Transient Adrenaline Receptor

Abstract:

Gamma-3 subunit of transient receptor potential (TARP) is a G protein-coupled receptor that plays a crucial role in various physiological processes. The CACNG3 gene has been identified as a potential drug target and biomarker for gamma-3 subunit. This article summarizes the current understanding of CACNG3, its potential drug implications, and its potential as a biomarker for various psychiatric and neurological disorders.

Introduction:

G protein-coupled receptors (GPCRs) are a family of transmembrane proteins that play a pivotal role in cellular signaling. GPCRs are composed of extracellular loop (ECL), transmembrane segment (TMS), and intracellular loop (ICL) regions. GPCRs are involved in various physiological processes, including sensory perception, neurotransmission, and cellular signaling. The GPCR family consists of 7 subunits, with each subunit having a unique structure and function.

Gamma-3 (CACNG3) is one of the GPCR subunits that has been well-studied. Gamma-3 is involved in the regulation of neurotransmitter release and is a potential drug target in various psychiatric and neurological disorders. The CACNG3 gene has been identified as a potential drug target and biomarker for gamma-3 subunit.

Current Understanding of CACNG3:

CACNG3 is a 21-kDa protein that consists of 154 amino acid residues. It has a unique structure, including a catalytic active site, a transmembrane region, and an intracellular loop (ICL) region. The CACNG3 protein is expressed in various tissues, including brain, heart, and pancreas.

Studies have shown that CACNG3 is involved in various physiological processes, including neurotransmission, cellular signaling, and stress response. G?±-linked signaling pathways have been identified as involved in CACNG3-mediated signaling. These pathways include G?±-dependent signaling, G?±-independent signaling, and negative signaling pathways.

Potential Drug Implications:

CACNG3 has been identified as a potential drug target for various psychiatric and neurological disorders. Studies have shown that dysregulation of GPCR signaling pathways, including changes in the levels of GPCR subunits, such as CACNG3, can contribute to the development of these disorders.

CACNG3 has been shown to play a role in the regulation of neurotransmission, including the regulation of dopamine release. Studies have shown that CACNG3 is involved in the regulation of dopamine release from the ventral tegmental area (VTA) of the midbrain. This is important for the regulation of mood, motivation, and reward.

In addition to its role in neurotransmission, CACNG3 has also been shown to play a role in stress response. Studies have shown that CACNG3 is involved in the regulation of cellular stress responses, including the regulation of cortical stress responses and the modulation of anxiety-like behaviors.

Potential Biomarker:

CACNG3 has also been shown to be a potential biomarker for various psychiatric and neurological disorders. Studies have shown that changes in the levels of CACNG3 can be associated with the development of psychiatric disorders, including depression, anxiety, and schizophrenia.

CACNG3 has also been shown to be involved in the regulation of neurotransmission, making it an attractive biomarker for

Protein Name: Calcium Voltage-gated Channel Auxiliary Subunit Gamma 3

Functions: Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state

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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   advantages and risks of development, etc.
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