ATP2B2: A Protein Targeted for Cancer and Neurodegenerative Diseases

Target Name: ATP2B2

NCBI ID: G491

ATP2B2

ATP2B2: A Protein Targeted for Cancer and Neurodegenerative Diseases

ATP2B2 is a protein that is expressed in most tissues of the body and is involved in the intracellular signaling pathway known as the cAMP/PKA pathway. This pathway is involved in the regulation of various cellular processes including muscle contractions, cell signaling, and intracellular signaling. The cAMP/PKA pathway is a well-established signaling pathway that is known to play a crucial role in the regulation of cellular processes that are critical for the maintenance of life.

Despite the importance of the cAMP/PKA pathway, several diseases are characterized by the dysregulation of this pathway. For example, various types of cancer, including breast, ovarian, and prostate cancers, have been identified as having altered levels of the protein ATP2B2. Additionally, the cAMP/PKA pathway is also known to be involved in the regulation of pain perception and neurodegenerative diseases.

The search for potential drug targets and biomarkers has led to the focus of this review being on the protein ATP2B2. This protein is of interest as a potential drug target due to its involvement in the cAMP/PKA pathway and its role in the regulation of various cellular processes.

ATP2B2: Structure and Function

ATP2B2 is a 22kDa protein that is expressed in most tissues of the body. It is a member of the protein family of ATP-binding proteins (PBPs) and is characterized by a single transmembrane domain and a unique N-terminal region that is rich in amino acids. The N-terminal region of ATP2B2 is known as the ATP-binding domain and is responsible for the protein's ability to bind to ATP.

The ATP-binding domain of ATP2B2 is a critical region that is involved in the regulation of various cellular processes. This domain is known to be involved in the regulation of the cAMP/PKA pathway and is thought to play a role in the regulation of cellular signaling. Additionally, the N-terminal region of ATP2B2 is also involved in the regulation of the production of reactive oxygen species (ROS), a pro-inflammatory molecule that can contribute to the development of various diseases.

ATP2B2 is involved in the regulation of several cellular processes that are critical for the maintenance of life. For example, ATP2B2 is involved in the regulation of muscle contractions and in the regulation of the production of hormones. Additionally, ATP2B2 is also involved in the regulation of the production of neurotransmitters, such as dopamine and serotonin, which are critical for the maintenance of proper brain function.

Mutations in the ATP2B2 gene have been identified as being associated with a number of diseases, including cancer and neurodegenerative diseases. For example, mutations in the ATP2B2 gene have been identified as being associated with the development of breast cancer. Additionally, mutations in the ATP2B2 gene have also been identified as being associated with the development of various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

Drug Targeting

The potential drug targeting of ATP2B2 is based on its involvement in the cAMP/PKA pathway and its role in the regulation of various cellular processes. Drugs that target ATP2B2 have the potential to treat a number of diseases, including cancer and neurodegenerative diseases.

One approach to drug targeting of ATP2B2 is the use of small molecules that can modulate the activity of ATP2B2. For example, a number of small molecules have been shown to have the potential to inhibit the

Protein Name: ATPase Plasma Membrane Ca2+ Transporting 2

Functions: ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:17234811, PubMed:15829536). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:17234811, PubMed:15829536). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:17234811, PubMed:15829536). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:17234811, PubMed:15829536). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity)

The "ATP2B2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ATP2B2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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