Unlocking the Potential of ATPase2C2 as a Drug Target and Biomarker

Target Name: ATP2C2

NCBI ID: G9914

ATP2C2

Unlocking the Potential of ATPase2C2 as a Drug Target and Biomarker

Introduction

ATP (adenylate triphosphate) is a crucial energy supplier in all living cells. It is a small molecule that stores and transfers energy from one molecule to another. ATP has a high energy density, which makes it an attractive target for drug developers. In recent years, several studies have identified potential drug targets and biomarkers associated with ATPase2C2, a protein that plays a critical role in ATP production and metabolism. In this article, we will explore the potential of ATPase2C2 as a drug target and biomarker.

The Importance of ATP in Cellular Function

ATP is involved in various cellular processes, including muscle contraction, nerve transmission, and cell signaling. It is the primary source of energy for the majority of cellular activities, which makes it a critical molecule for the proper functioning of cells. When ATP is broken down, it releases energy in the form of ADP (adenylate diphosphate) and Pi (phosphocreatine). These molecules can then be used to perform additional energy-producing processes in the cell.

ATPase2C2: The Catalyst for ATP Synthesis

ATPase2C2 is a protein that plays a crucial role in ATP production and metabolism. It is an enzyme that catalyzes the transfer of a phosphate group from a phosphate donor to an ATP synthase II complex. This transfer of a phosphate group creates a high-energy bond that can be used to generate ATP. ATPase2C2 is essential for the production of ATP, which is the primary source of energy for the majority of cellular activities.

ATPase2C2 is also involved in the regulation of ATP levels in the cell. It can act as a negative regulator, limiting the amount of ATP produced and maintaining ATP levels in the cell. This regulation is important for maintaining cellular homeostasis and for the prevention of ATP -dependent processes that can be harmful to the cell.

Drug Targets and Biomarkers for ATPase2C2

Several studies have identified potential drug targets and biomarkers associated with ATPase2C2. These include:

1. ATPase2C2-mediated signaling cascades: Several studies have identified signaling cascades that involve ATPase2C2. These cascades play important roles in cellular processes, including cell signaling, DNA replication, and metabolism. Identifying potential drug targets and biomarkers associated with these cascades could lead to new therapeutic strategies.
2. ATPase2C2-regulated cellular processes: ATPase2C2 is involved in various cellular processes, including cell signaling, muscle contraction, and vasodilation. Identifying potential drug targets and biomarkers associated with these processes could lead to new therapeutic strategies for treating various diseases.
3. ATPase2C2-mediated cellular responses: ATPase2C2 is involved in the regulation of cellular responses to various stimuli, including nutrients, toxins, and drugs. Identifying potential drug targets and biomarkers associated with these responses could lead to new therapeutic strategies for treating various diseases.

Biomarkers for ATPase2C2

ATPase2C2 is involved in various cellular processes, which makes it an attractive target for biomarkers. Several studies have identified potential biomarkers associated with ATPase2C2, including:

1. Plasma ATP levels: Plasma ATP levels can be used as a biomarker for the evaluation of the activity of ATPase2C2. Studies have shown that changes in plasma ATP levels can be associated with various diseases, including heart disease, diabetes, and cancer. Identifying potential drugs that can increase plasma ATP levels could be a potential therapeutic strategy for treating these diseases.
2. Uptake of ATP by cancer cells: Cancer cells have unique requirements for ATP, which allows them to survive and grow. The uptake of ATP by cancer cells has

Protein Name: ATPase Secretory Pathway Ca2+ Transporting 2

Functions: ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:15831496, PubMed:16332677, PubMed:30923126, PubMed:15677451). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:15831496, PubMed:16332677). Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus (PubMed:23840669, PubMed:20887894)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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