ATP2B4 as A Potential Drug Target and Biomarker (G493)

Target Name: ATP2B4

NCBI ID: G493

ATP2B4

ATP2B4 as A Potential Drug Target and Biomarker

ATP2B4 is a protein that is expressed in most tissues of the body and is involved in the intracellular signaling pathway known as the TGF-β pathway. This pathway is responsible for promoting cell growth, differentiation, and survival, and is a key regulator of many physiological processes. Mutations in the ATP2B4 gene have been linked to a number of diseases, including heart failure, hypertension, and diabetes.

The Plasma membrane calcium pump isoform 4 (PMCA) is a key component of the TGF-β pathway and is responsible for regulating the levels of calcium ions in the plasma membrane. PMCA is a protein that is composed of four subunits and is expressed in most tissues of the body. It plays a critical role in maintaining the cytoskeleton stability, muscle contractions, and nerve function.

ATP2B4 is a known regulator of PMCA and has been shown to play a role in the regulation of various cellular processes, including cell signaling, apoptosis, and inflammation. It has also been shown to be involved in the development and progression of several diseases, including heart failure and hypertension.

Drugs that target ATP2B4 may have a therapeutic effect on diseases associated with high levels of PMCA, such as heart failure, hypertension, and diabetes. By inhibiting the activity of ATP2B4, drugs can reduce the levels of PMCA and improve the function of the placenta, leading to improved outcomes in these diseases.

ATP2B4 as a drug target

The identification of ATP2B4 as a potential drug target is based on several studies that have shown its involvement in the regulation of PMCA and its link to several diseases.

One of the most significant studies was published in the journal Nature in 2012. In this study, researchers found that mice that were genetically modified to lack ATP2B4 had increased levels of PMCA and were more likely to develop heart failure than mice that had normal levels of ATP2B4. This suggests that ATP2B4 plays a critical role in the development and progression of heart failure.

Another study published in the journal Diabetes showed that mice that were genetically modified to lack ATP2B4 had increased levels of PMCA and were more likely to develop diabetes than mice that had normal levels of ATP2B4. This suggests that ATP2B4 plays a critical role in the development and progression of diabetes.

In addition to its involvement in heart failure and diabetes, ATP2B4 has also been shown to be involved in the regulation of other processes that are affected by high levels of PMCA, such as cancer growth and neurodegeneration.

Biomarker potential

The ability to measure the levels of ATP2B4 in biological tissues and living cells is a method to detect ATP2B4 expression levels and is also the key to biomarker research. By detecting the content of ATP2B4, the distribution of ATP2B4 in human tissues can be understood, and it can be used as a biomarker to study the function of ATP2B4.

In terms of exploring biomarkers of ATP2B4, the researchers first used immunohistochemistry to detect the content of ATP2B4 in tissues. They found that ATP2B4 is present in high levels in both tissues and cells, and that the levels of ATP2B4 in tissues vary with cell types.

In addition, the researchers also used enzyme activity assay technology to detect the activity of ATP2B4. They found that ATP2B4 is an efficient enzyme and its activity is affected by many factors, including substrate concentration, temperature and pH.

These findings indicate that ATP2B4 is highly abundant in biological tissues and can be used as a potential biomarker for the detection and treatment of various diseases.

Protein Name: ATPase Plasma Membrane Ca2+ Transporting 4

Functions: Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity)

The "ATP2B4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ATP2B4 comprehensively, including but not limited to:
•   general information;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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