ATP5ME: A Protein Involved in ATP Synthesis and Hydrogen Transport in The Mitochondria

Target Name: ATP5ME

NCBI ID: G521

ATP5ME

ATP5ME: A Protein Involved in ATP Synthesis and Hydrogen Transport in The Mitochondria

ATP5ME, also known as ATP synthase subunit E, is a protein that plays a critical role in the process of ATP synthesis and hydrogen transport in the mitochondria. It is a subunit of the mitochondrial F0 complex, which is responsible for importing foreign particles, including hydrogen, into the mitochondria. The F0 complex is composed of several subunits, including ATP5ME, which is responsible for importing hydrogen into the mitochondria via a process called proton motive force (PMF).

ATP5ME is a 23-kDa protein that consists of 156 amino acids. It has a unique structure that allows it to interact with the F0 complex and specifically with the subunit A, which is responsible for importing protons into the mitochondria. ATP5ME has a catalytic active site that is located at the base of the protein and is responsible for the transfer of a phosphate group to F0 to initiate the ATP synthesis process.

One of the unique features of ATP5ME is its ability to transport protons through the F0 complex. This is critical for the maintenance of the proton gradient, which is essential for the function of the mitochondria. The F0 complex is composed of several subunits, including ATP5ME, which is responsible for importing hydrogen into the mitochondria via a process called proton motive force (PMF). PMF uses the energy from the ATP to pump protons through the F0 complex.

ATP5ME is also involved in the regulation of the activity of the F0 complex. It has been shown to play a role in the inhibition of the activity of the complex, which is thought to be important for the regulation of ATP synthesis and the maintenance of the proton gradient. Additionally, ATP5ME has been shown to regulate the stability of the F0 complex, which is critical for the stability of the proton gradient.

In addition to its role in the F0 complex, ATP5ME is also involved in the regulation of the activity of other cellular processes. It has been shown to play a role in the regulation of the activity of the bacterial flagellum, which is responsible for the movement of cells. Additionally, ATP5ME has been shown to play a role in the regulation of the activity of the mitochondrial outer membrane protein, which is responsible for the structure and function of the mitochondrial membrane.

Given its critical role in the process of ATP synthesis and hydrogen transport in the mitochondria, it is a potential drug target for the treatment of various diseases. For example, ATP5ME has been shown to be involved in the regulation of the activity of the F0 complex, which is thought to be important for the regulation of ATP synthesis and the maintenance of the proton gradient. Therefore, inhibitors of ATP5ME may be useful for the treatment of various diseases, including cancer, neurodegenerative diseases, and respiratory diseases.

In conclusion, ATP5ME is a protein that plays a critical role in the process of ATP synthesis and hydrogen transport in the mitochondria. It is a subunit of the mitochondrial F0 complex and is responsible for the transfer of a phosphate group to F0 to initiate the ATP synthesis process. Additionally, ATP5ME is involved in the regulation of the activity of the F0 complex and has been shown to play a role in the inhibition of the activity of the complex. Given its critical role in these processes, it is a potential drug target for the treatment of various diseases.

Protein Name: ATP Synthase Membrane Subunit E

Functions: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane

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