ATP5MK: A Protein Regulator of Cellular Respiration and Ion Water Balance

Target Name: ATP5MK

NCBI ID: G84833

ATP5MK

ATP5MK: A Protein Regulator of Cellular Respiration and Ion Water Balance

ATP5MK (also known as MC5DN6) is a protein that is expressed in various tissues and organs, including the brain, heart, and kidneys. It is a key regulator of the ATPase, a protein that is involved in the production and regulation of ATP, the energy currency of the cell.

ATP is produced by the body through a process called cellular respiration, in which glucose is broken down to produce energy in the form of ATP. The ATPase enzyme is the critical regulator of this process, as it controls the flow of ATP out of the cell and into the cell membrane.

ATP5MK is a 55 kDa protein that is composed of 55% alpha-helices and 45% beta-helices. It is expressed in a variety of tissues and organs, including the brain, heart, and kidneys, and is involved in the regulation of cellular respiration, the production and response to stimuli, and the regulation of ion and water balance.

One of the key functions of ATP5MK is its role in regulating the production of ATP. It is a negative regulator of the ATPase enzyme, which means that when the concentration of ATP in the cell is high, the ATPase enzyme is inhibited, and the production of ATP is reduced. Conversely, when the concentration of ATP is low, the ATPase enzyme is activated, and the production of ATP is increased.

ATP5MK is also involved in the regulation of the rate of cellular respiration. It is a critical regulator of the rate at which glucose is broken down to produce ATP, and it is thought to play a key role in the regulation of muscle tension and blood pressure.

In addition to its role in regulating ATP production and cellular respiration, ATP5MK is also involved in the regulation of ion and water balance. It is a regulator of the diffusion of ions and water across the cell membrane, and is thought to play a key role in the regulation of the blood volume and blood pressure.

The research on ATP5MK is still in its early stages, and much more research is needed to fully understand its role in the regulation of cellular respiration and other processes. However, the potential implications of ATP5MK as a drug target or biomarker are significant. If its role in the regulation of ATP production and cellular respiration is confirmed, it may be a promising target for the development of new treatments for a variety of diseases, including cancer, heart disease, and neurological disorders.

Protein Name: ATP Synthase Membrane Subunit K

Functions: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (PubMed:29917077). ATP5MK is a minor subunit of the mitochondrial membrane ATP synthase required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria (PubMed:21345788, PubMed:29917077)

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