ZDHHC24: A Potential Drug Target and Biomarker for Proliferative disorders

Target Name: ZDHHC24

NCBI ID: G254359

ZDHHC24

ZDHHC24: A Potential Drug Target and Biomarker for Proliferative disorders

Introduction

Proliferative disorders are a group of diseases characterized by the uncontrolled growth and proliferation of cells, leading to the formation of tumors. These disorders affect various organs and tissues, including blood vessels, skin, hair, and the nervous system, and can lead to serious health consequences if left untreated. The understanding of the molecular mechanisms underlying these processes is crucial for the development of effective therapies. In recent years, significant progress has been made in the identification of potential drug targets and biomarkers for these disorders. In this article, we will explore ZDHHC24, a gene that has been identified as a potential drug target and biomarker for proliferation disorders.

The ZDHHC24 gene

The ZDHHC24 gene is located on chromosome 6p21.2 and encodes a protein known as ZDHHC24. ZDHHC24 is a member of the ZDHHC gene family, which is characterized by the presence of a single transmembrane domain and a C-terminal hypervariable region (HVR). ZDHHC24 is expressed in various tissues and organs, including blood vessels, skin, and hair, and has been implicated in the development and progression of several proliferation disorders.

Function and regulation of ZDHHC24

ZDHHC24 is involved in the transfer of fatty acids from the cell membrane to the cytosol. This process is critical for the maintenance of cellular energy homeostasis and is dynamically regulated by various factors, including changes in membrane potential and the availability of fatty acids. ZDHHC24 is a key regulator of this process, as it is involved in the formation of mitochondrial organelles, including mitochondrial fatty acid-binding proteins (MFABs), which are responsible for transporting fatty acids to the mitochondria for oxidation.

In addition to its role in fatty acid transport, ZDHHC24 is also involved in the regulation of cellular signaling pathways that promote cell growth and proliferation. One of its most significant functions is the regulation of the PI3K/Akt signaling pathway, which is a well- established regulator of cell survival and proliferation. ZDHHC24 has been shown to play a negative role in this pathway, as it has been shown to inhibit the activity of the protein kinase Akt (PKA) and to enhance the negative impact of the PI3K signaling pathway on cell proliferation.

Drug targeting ZDHHC24

The ZDHHC24 gene has been identified as a potential drug target for several proliferation disorders. The most promising approach for targeting ZDHHC24 is the use of small molecules that can modulate its activity. One of the most well-studied small molecules is curcumin, which is an alkaloid found in turmeric, a spice commonly used in Indian cuisine. Curcumin has been shown to have anti-inflammatory and anti-proliferative effects and has been shown to inhibit the activity of ZDHHC24 in cell culture models of cancer and other proliferation disorders.

In addition to its effects on ZDHHC24, curcumin has also been shown to have several other potential therapeutic benefits. It has been shown to have anti-inflammatory effects, as well as effects on cellular signaling pathways that promote cell survival and proliferation. These properties make Curcumin is an attractive candidate for the treatment of various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders.

Biomarker assessment

The use of biomarkers is an important step in the development of new drugs for proliferation disorders. By using biomarkers to monitor the effectiveness of new treatments, researchers can determine whether a treatment is effective and identify potential biomarkers for

Protein Name: Zinc Finger DHHC-type Containing 24

Functions: Probable palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates

The "ZDHHC24 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZDHHC24 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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