NOCT: A Protein Involved in GPCR Signaling and Ion Channel Regulation

Target Name: NOCT

NCBI ID: G25819

NOCT

NOCT: A Protein Involved in GPCR Signaling and Ion Channel Regulation

NOCT (NOCT_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, muscle, heart, and liver. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a key role in cellular signaling.

NOCT is unique because of its ability to interact with multiple GPCR signaling pathways, making it a promising drug target for a variety of diseases. One of the ways that NOCT interacts with GPCR signaling pathways is through its role in the regulation of ion channels, which are responsible for the flow of electrical current through cells.

NOCT has been shown to play a role in the regulation of ion channels in a variety of tissues and organs, including the brain. For example, studies have shown that NOCT is involved in the regulation of the activity of the sodium ion (Na+) channels , which are important for the flow of electrical current through the brain.

In addition to its role in ion channel regulation, NOCT has also been shown to play a role in the regulation of cell signaling pathways. For example, studies have shown that NOCT is involved in the regulation of the production of signaling molecules, such as neurotransmitters , which are important for communication between cells.

NOCT is also unique because of its ability to interact with multiple GPCR signaling pathways. This means that it can be a drug target for a variety of diseases that involve the regulation of ion channels or cell signaling pathways.

In conclusion, NOCT is a protein that is expressed in various tissues of the human body and is involved in the regulation of ion channels and cell signaling pathways. Its unique ability to interact with multiple GPCR signaling pathways makes it a promising drug target for a variety of diseases. Further research is needed to fully understand the role of NOCT in disease and to develop effective treatments.

Protein Name: Nocturnin

Functions: Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity)

The "NOCT Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NOCT comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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