Trav8-1: A Potential Drug Target Or Biomarker (G28685)

Target Name: TRAV8-1

NCBI ID: G28685

TRAV8-1

Other Name(s): TCRAV1S1 | TRAV81 | TCRAV8S1 | T cell receptor alpha variable 8-1

Trav8-1: A Potential Drug Target Or Biomarker

Trav8-1 (TRAV8-1), a protein that is expressed in various tissues of the body, including the brain, has been identified as a potential drug target or biomarker. The protein is a member of the tyrosine kinase family and is involved in the regulation of cellular processes that are crucial for brain development, function, and disease.

Trav8-1 is a 21-kDa protein that is expressed in the brain, heart, liver, and kidneys. It is highly conserved across species, which suggests that it has a conserved function. The protein is localized to the endoplasmic reticulum (ER) and has been shown to be involved in the regulation of several cellular processes, including cell survival, proliferation, and differentiation.

One of the key functions of Trav8-1 is its role in the regulation of cell survival. The protein has been shown to play a role in the regulation of cell survival by promoting the survival of neurons and other cell types. This is important because neurons are critical for the function and structure of the brain, and the loss of neurons can lead to a variety of neurological and psychiatric disorders.

Another function of Trav8-1 is its role in the regulation of cell proliferation. The protein has been shown to play a role in the regulation of cell proliferation by promoting the growth and survival of cells. This is important because the growth and proliferation of cells are critical for the development and maintenance of tissues and organs.

Trav8-1 is also involved in the regulation of cell differentiation. The protein has been shown to play a role in the regulation of cell differentiation by promoting the stability and diversity of gene expression. This is important because the regulation of cell differentiation is critical for the development and maintenance of tissues and organs, and the regulation of cell differentiation is often disrupted in diseases such as cancer.

In addition to its role in cell survival and proliferation, Trav8-1 is also involved in the regulation of several other cellular processes. The protein has been shown to play a role in the regulation of cell migration, which is critical for the development and maintenance of tissues and organs. The protein has also been shown to play a role in the regulation of cell adhesion, which is important for the formation of tissues and organs.

Trav8-1 is also involved in the regulation of several signaling pathways. The protein has been shown to play a role in the regulation of the TGF-β pathway, which is a critical pathway involved in the regulation of cell growth, differentiation, and survival. The TGF-β pathway is a well-established pathway that is involved in the development and maintenance of tissues and organs, and the regulation of the TGF-β pathway is important for the development and maintenance of tissues and organs.

In conclusion, Trav8-1 is a protein that is involved in several critical cellular processes that are crucial for the development and maintenance of tissues and organs. The protein is highly conserved across species and has been shown to play a role in the regulation of cell survival, proliferation, differentiation, and several other cellular processes. Therefore, Trav8-1 is a potential drug target or biomarker for several diseases. Further research is needed to fully understand the functions of Trav8-1 and its potential as a drug target or biomarker.

Protein Name: T Cell Receptor Alpha Variable 8-1

Functions: V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

The "TRAV8-1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRAV8-1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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