Identifying Potential Drug Targets and Biomarkers for NMNAT3 (G349565)

Target Name: NMNAT3

NCBI ID: G349565

NMNAT3

Identifying Potential Drug Targets and Biomarkers for NMNAT3

NMNAT3 (NMNAT3 variant 1) is a gene that encodes a protein known as nanosome-associated protein 3 (NAP-3). NAP-3 is a 22-kDa protein that is expressed in various tissues and cell types, including brain, heart, and pancreas. It is involved in the regulation of a variety of cellular processes, including cell signaling, DNA replication, and stress responses.

The search for potential drug targets and biomarkers is an important aspect of modern medicine. Drug development involves identifying small molecules or biochemicals that can interact with specific targets to either inhibit or activate protein kinases, leading to therapeutic effects. Biomarkers are proteins or genetic material that can be used to diagnose or monitor disease. In this article, we will explore the potential drug target and biomarker properties of NMNAT3.

Drug Target Potential

NMNAT3 has been identified as a potential drug target due to its involvement in various cellular processes that are associated with the development and progression of a variety of diseases. One of the key features of NMNAT3 is its role in the regulation of cellular signaling pathways. NAP -3 has been shown to play a role in the regulation of several signaling pathways, including the TGF-β pathway, the Wnt pathway, and the Hedgehog pathway.

The TGF-β pathway is involved in the regulation of cell growth, differentiation, and inflammation. It is a well-established drug target and has been the focus of much research in recent years. The TGF-β pathway is activated by a variety of factors, including growth factors, physical stimulation, and cellular stress. NAP-3 has been shown to play a role in the regulation of TGF-β signaling by negatively regulating the activity of the transcription factor SMAD.

The Wnt pathway is involved in the regulation of cell-cell adhesion and the development of tissues. It is a critical pathway for the development and maintenance of tissues and organs, including neural tissue. NAP-3 has been shown to play a role in the regulation of Wnt signaling by regulating the activity of the transcription factor LGR5.

The Hedgehog pathway is involved in the regulation of cell growth and stability. It is a critical pathway for the development and maintenance of tissues and organs, including blood vessels and bones. NAP-3 has been shown to play a role in the regulation of Hedgehog signaling by regulating the activity of the transcription factor FGF1.

Biomarker Properties

In addition to its role in cellular signaling pathways, NMNAT3 has also been identified as a potential biomarker for several diseases. One of the key features of NMNAT3 is its expression in various tissues and cell types, which makes it a potential biomarker for a variety of diseases.

NMNAT3 has been shown to be expressed in a variety of tissues and has been used as a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and cardiovascular disease. For example, studies have shown that NMNAT3 is expressed in various types of cancer, including breast, ovarian, and colorectal cancer. It has also been used as a potential biomarker for neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In addition to its potential as a biomarker, NMNAT3 has also been shown to be involved in the regulation of cellular processes that are associated with the development and progression of these diseases. For example, studies have shown that NMNAT3 is involved in the regulation of neuroinflammation , which is thought to play a role in the development and progression of neurodegenerative diseases.

Conclusion

In conclusion, NMNAT3 is a gene that encodes a protein that is involved in the regulation of various cellular processes that are associated with the development and progression of diseases. Its potential as a drug target and biomarker makes it an attractive target for further research. Further studies are needed to fully understand the role of NMNAT3 in

Protein Name: Nicotinamide Nucleotide Adenylyltransferase 3

Functions: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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