NMT2 and GPT-2: Potential Drug Targets (G9397)

Target Name: NMT2

NCBI ID: G9397

NMT2

NMT2 and GPT-2: Potential Drug Targets

NMT2 (N-tetradecanoyltransferase 2) is a gene that encodes a protein involved in the metabolism of lipids in the body. Specifically, it is involved in the transfer of N-tetradecanoyl groups from other lipids to theacylCoA esters, which are then involved in the production of energy. The encoded protein has been shown to play a role in the regulation of lipid metabolism and has been implicated in a number of diseases, including obesity, diabetes, and cardiovascular disease.

The Glycylpeptide N-Tetradecanoyl Transferase 2 (GPT-2) variant 4 is a specific isoform of the NMT2 gene that has been shown to be involved in the production of N-tetradecanoyl lipids. GPT-2 has been shown to have a number of unique features that make it a potential drug target.

NMT2 and GPT-2

NMT2 is a member of the family of transferases that belong to the lipid metabolism pathway. This pathway is involved in the production and breakdown of lipids in the body, and the NMT2 protein is involved in the transfer of N-tetradecanoyl groups from other lipids to theacylCoA esters. This process is critical for the production of energy and is also involved in the regulation of lipid levels and the development of certain diseases.

GPT-2 is a specific isoform of the NMT2 gene that has been shown to be involved in the production of N-tetradecanoyl lipids. This is done through a unique mechanism that involves the transfer of a N-tetradecanoyl group from another lipid to theacylCoA esters. This process is critical for the production of N-tetradecanoyl lipids, which are involved in the production of energy and are also involved in the regulation of lipid levels.

Drug Target Potential

GPT-2 has been shown to have a number of unique features that make it a potential drug target. One of the main advantages is its ability to produce N-tetradecanoyl lipids, which can be used as a source of energy. This makes GPT-2 an attractive target for drugs that are designed to improve energy metabolism and overall health.

Another advantage of GPT-2 is its role in the regulation of lipid levels. GPT-2 has been shown to play a role in the regulation of lipid levels and has been implicated in the development of certain diseases, such as obesity and cardiovascular disease. This makes GPT-2 an attractive target for drugs that are designed to regulate lipid levels and improve overall health.

In addition, GPT-2 has been shown to have a unique structure that makes it resistant to many conventional drug treatments. This makes it an attractive target for drugs that are designed to be effective in treating a wide range of conditions.

Conclusion

GPT-2 is a unique protein that has been shown to play a role in the production of N-tetradecanoyl lipids and the regulation of lipid levels. Its unique structure and ability to produce N-tetradecanoyl lipids make it an attractive target for drugs that are designed to improve energy metabolism and overall health. Further research is needed to fully understand the role of GPT-2 in the regulation of lipid levels and to develop effective treatments for the associated diseases.

Protein Name: N-myristoyltransferase 2

Functions: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:25255805, PubMed:9506952). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017)

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