NNT: A Protein Implicated in Many Diseases (G23530)

Target Name: NNT

NCBI ID: G23530

Content of Review Report on NNT Target / Biomarker

NNT

NNT: A Protein Implicated in Many Diseases

NNT, or Nicotinamide adenine dinucleotide (phosphate) transhydrogenase, is a protein that is expressed in various cell types throughout the body. It plays a crucial role in the regulation of DNA replication, repair, and cell growth. The NNT gene has been implicated in the development and progression of many diseases, including cancer, neurodegenerative diseases, and reproductive disorders. As a result, NNT has become a focus of interest for researchers and pharmaceutical companies alike.

The NNT protein is composed of two subunits, NNT1 and NNT2, which are located on opposite ends of a double helix. NNT1 is the catalytic subunit, responsible for the transfer of electrons during the DNA replication process. NNT2, on the other hand, is the structural subunit, which provides the protein with its unique structure and stability.

NNT has been shown to play a critical role in the regulation of DNA replication. During DNA replication, NNT1 helps to ensure that the two new strands of DNA are properly complementary and that the replication process is performed accurately. NNT has also been shown to be involved in the repair of DNA damage, which is a critical aspect of DNA replication that can result in the development of cancer.

In addition to its role in DNA replication, NNT has also been shown to be involved in the regulation of cell growth and the development of neurodegenerative diseases. NNT has been shown to play a negative role in the growth and development of cancer cells, by inhibiting the formation of these cells. In addition, NNT has also been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, by contributing to the build-up of neuro-invasive proteins in the brain.

NNT has also been shown to be involved in the regulation of reproductive processes, which is critical for the development and progression of reproductive disorders. NNT has also been shown to play a role in the regulation of meiosis, the process by which a cell divides into four cells with the same number of chromosomes, and has been shown to contribute to the development of reproductive disorders.

Due to its involvement in the regulation of DNA replication, repair, and cell growth, NNT has become a focus of interest for researchers and pharmaceutical companies. Many drugs that have been developed to treat various diseases have been shown to target NNT, with the goal of inhibiting its activity or modulating its expression.

One of the most promising strategies for targeting NNT is the use of small molecules, such as those that inhibit the activity of NNT1 or NNT2. These molecules have been shown to be effective in treating various diseases, including cancer, neurodegenerative diseases, and reproductive disorders.

Another approach to targeting NNT is the use of monoclonal antibodies, which are a type of immunotherapy that can be used to selectively target a specific protein. Monoclonal antibodies have been shown to be effective in treating various diseases, including cancer, by selectively binding to the target protein and inhibiting its activity.

In addition to these therapeutic approaches, there is also significant interest in the use of NNT as a drug or biomarker. The NNT gene has been shown to be involved in the regulation of various cellular processes, including DNA replication, repair, and cell growth. As a result, the NNT gene has the potential to serve as a drug target or biomarker for a variety of diseases.

For example, NNT has been shown to be involved in the regulation of cancer cell growth and has been shown to be a potential therapeutic target for cancer. In addition, NNT has also been shown to be involved in the regulation of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases

Protein Name: Nicotinamide Nucleotide Transhydrogenase

Functions: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (PubMed:22634753)

The "NNT Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NNT comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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