KRTAP20-1: A Potential Drug Target and Biomarker (G337975)

Target Name: KRTAP20-1

NCBI ID: G337975

KRTAP20-1

Other Name(s): KAP20.1 | KR201_HUMAN | Keratin associated protein 20-1 | keratin associated protein 20-1 | Keratin-associated protein 20-1

KRTAP20-1: A Potential Drug Target and Biomarker

Kapaptenin-converting enzyme (KRTAP) is a family of proteins that are involved in the detoxification of xenobiotics, such as pesticides and other environmental toxins, in the liver. Enzymes of this family are also known as cytochrome P450 enzymes, and their activities are regulated by multiple intracellular signaling pathways. One of the best-studied members of this family is KRTAP20.1 (KAP20.1), which is a protein that is expressed in various tissues and organs in the body and is involved in the detoxification of xenobiotics.

The KRTAP20 gene is located on chromosome 6 and encodes a protein that has a molecular weight of approximately 120 kDa. This protein is highly conserved across various species, and it has been shown to have multiple functions in various cellular processes, including cell signaling, DNA replication, and drug resistance. One of the most interesting functions of KRTAP20 is its role in drug resistance.

KRTAP20 is known to be involved in the detoxification of a wide variety of xenobiotics, including pesticides and other environmental toxins. This is achieved through its ability to convert xenobiotics to less toxic metabolites. For example, KRTAP20 has been shown to convert the toxic pesticide pesticide-1 (PA1042) to its less toxic metabolite, 1042-N-oxide, via a process called oxidative N-dealkylation. This reaction is critical for the detoxification of PA1042, which is commonly used in the control of termite infestations.

In addition to its role in drug detoxification, KRTAP20 is also involved in cell signaling and DNA replication. This is achieved through its ability to interact with various intracellular signaling pathways, including the cAMP/cGMP signaling pathway, the extrinsic signaling pathway, and the DNA replication pathway.

KRTAP20 is also involved in the detoxification of xenobiotics through its role in the cytochrome P450 enzyme system. This system is responsible for metabolizing a wide variety of drugs and other substances in the body. The cytochrome P450 enzymes have multiple substrates and can be divided into three classes: aryl hydrocarbon (Ah) metabolites, electrophile (E) metabolites, and xenobiotics (X) metabolites. KRTAP20 is one of the X metabolites and is involved in the detoxification of a wide variety of xenobiotics, including pesticides and other environmental toxins.

KRTAP20's role in drug resistance and detoxification is also critical for the development of cancer. Enzymes of the cytochrome P450 system have been implicated in the development and progression of many types of cancer, including breast, ovarian, and prostate cancers. Therefore, targeting the activity of KRTAP20 and other cytochrome P450 enzymes may be a promising strategy for the development of cancer therapies.

In conclusion, KRTAP20 is a protein that is involved in the detoxification of xenobiotics and has multiple functions in various cellular processes. Its role in drug resistance and detoxification is critical for the development and progression of cancer. Therefore, targeting the activity of KRTAP20 and other cytochrome P450 enzymes may be a promising strategy for the development of cancer therapies.

Protein Name: Keratin Associated Protein 20-1

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

The "KRTAP20-1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRTAP20-1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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